Literature DB >> 6197124

Evidence against vasoactive intestinal polypeptide (VIP) as a dilator and in favour of substance P as a constrictor in airway neurogenic responses.

J A Karlsson, C G Persson.   

Abstract

Propranolol-resistant neurogenic relaxation persisted in (carbachol-contracted) guinea-pig tracheae already relaxed by supramaximal concentrations of vasoactive intestinal polypeptide (VIP). Also, VIP relaxed preparations that were under neurogenic inhibition. In hilus bronchi, about 60% of a neurogenic contraction was atropine-resistant. (Arg5, D-Trp7.9) SP 5-11 specifically antagonized this contraction and those produced by exogenous substance P. Substance P, but not VIP, seems to be involved in nerve-mediated effects on guinea-pig airway tone.

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Year:  1983        PMID： 6197124      PMCID： PMC2044903          DOI： 10.1111/j.1476-5381.1983.tb09999.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

1.  Chemical design of antagonists of substance P.

Authors:  K Folkers; J Hörig; S Rosell; U Björkroth
Journal:  Acta Physiol Scand       Date:  1981-04

2.  Vasoactive intestinal peptide: a possible transmitter of nonadrenergic relaxation of guinea pig airways.

Authors:  Y Matsuzaki; Y Hamasaki; S I Said
Journal:  Science       Date:  1980-12-12       Impact factor: 47.728

3.  Influence of tracheal contraction on relaxant effects in vitro of theophylline and isoprenaline.

Authors:  J A Karlsson; C G Persson
Journal:  Br J Pharmacol       Date:  1981-09       Impact factor: 8.739

4.  Occurrence and distribution of VIP nerves in the nasal mucosa and tracheobronchial wall.

Authors:  R Uddman; J Alumets; O Densert; R Håkanson; F Sundler
Journal:  Acta Otolaryngol       Date:  1978 Nov-Dec       Impact factor: 1.494

5.  Pharmacological characterization of the autonomous innervation of the guinea pig tracheobronchial smooth muscle.

Authors:  N Grundström; R G Andersson; J E Wikberg
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1981-08

6.  A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig.

Authors:  J M Lundberg; A Saria; E Brodin; S Rosell; K Folkers
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205
  6 in total
  5 in total

1.  Possible role of calcium in neurotransmission to the lower airways.

Authors:  J G Widdicombe
Journal:  Br J Clin Pharmacol       Date:  1985       Impact factor: 4.335

2.  Relaxation of cat tracheobronchial and pulmonary arterial smooth muscle by vasoactive intestinal peptide: lack of influence by peptidase inhibitors.

Authors:  R J Altiere; L Diamond
Journal:  Br J Pharmacol       Date:  1984-06       Impact factor: 8.739

Review 3.  A role for capsaicin sensitive, tachykinin containing nerves in chronic coughing and sneezing but not in asthma: a hypothesis.

Authors:  J A Karlsson
Journal:  Thorax       Date:  1993-04       Impact factor: 9.139

4.  Involvement of capsaicin-sensitive afferent neurones in a vagal-dependent interaction between leukotriene D4 and histamine on bronchomotor tone.

Authors:  A G Stewart; D C Thompson; M R Fennessy
Journal:  Agents Actions       Date:  1984-12

5.  The effects of vasoactive intestinal peptide (VIP) antagonists, and VIP and peptide histidine isoleucine antisera on non-adrenergic, non-cholinergic relaxations of tracheal smooth muscle.

Authors:  J L Ellis; S G Farmer
Journal:  Br J Pharmacol       Date:  1989-03       Impact factor: 8.739
  5 in total

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