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Literature DB >> 6195518

Lipid-bound sugars in malignant human breast tumors. Partial characterization of mannosyl and glucosyl transferase activities.

A R Santa Cruz, L A Quesada Allue, A Baldi.

Abstract

Microsomal preparations from malignant human breast tumors catalyzed the transfer of mannose and glucose from GDP-[14C]-Man and UDP-[14C]-Glc into lipid-linked sugars and glycoprotein-like substances. As judged by several criteria the obtained lipid-linked monosaccharides behaved as dolichyl phosphate mannose and dolichyl phosphate glucose whereas lipid-linked oligosaccharides behaved as polyprenyl diphosphate derivatives. The optimum conditions for mannosyl- and glucosyl-transfer reactions and the effect of dolichyl phosphate, detergent and EDTA on incubation mixture were described.

Entities: Chemical Disease Species

Mesh：

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Year: 1983 PMID： 6195518 DOI： 10.1007/bf00228769

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

48 in total

1. Lipid linked sugars in glycoprotein synthesis.

Authors: W J Lennarz
Journal: Science Date: 1975-06-06 Impact factor: 47.728

2. Biosynthesis of polyprenol phosphate sugars by Ceratitis capitata extracts.

Authors: L A Quesada Allue; L R Maréchal; E Belocopitow
Journal: FEBS Lett Date: 1976-09-01 Impact factor: 4.124

3. The role of dolichol monophosphate in sugar transfer.

Authors: N H Behrens; A J Parodi; L F Leloir; C R Krisman
Journal: Arch Biochem Biophys Date: 1971-04 Impact factor: 4.013

4. Phosphorylation of dolichol by insect enzymes. The incorporation of phosphate from ATP into dolichyl phosphate mannose.

Authors: L A Quesada Allue
Journal: FEBS Lett Date: 1979-01-15 Impact factor: 4.124

10. Polysaccharide biosynthesis in Acetobacter xylinum. Enzymatic synthesis of lipid diphosphate and monophospate sugars.

Authors: R C García; E Recondo; M Dankert
Journal: Eur J Biochem Date: 1974-03-15

1 in total

1. Transfer of oligosaccharide from oligosaccharide pyrophosphoryl dolichol to endogenous acceptor proteins in human breast malignant and normal tissues.

Authors: A R Santa Cruz; A Baldi
Journal: Experientia Date: 1985-07-15

1 in total

Lipid-bound sugars in malignant human breast tumors. Partial characterization of mannosyl and glucosyl transferase activities.

1. Lipid linked sugars in glycoprotein synthesis.

2. Biosynthesis of polyprenol phosphate sugars by Ceratitis capitata extracts.

3. The role of dolichol monophosphate in sugar transfer.

4. Phosphorylation of dolichol by insect enzymes. The incorporation of phosphate from ATP into dolichyl phosphate mannose.

Review 5. Comparative aspects of glycoprotein structure.

6. Biosynthesis of lens glycoproteins. I. Formation of polyprenyl-linked saccharides in lens cell membranes.

7. Lipid-bound oligosaccharides in insects.

8. Glucose transfer from dolichol monophosphate glucose: the product formed with endogenous microsomal acceptor.

9. Abnormal lipid-linked oligosaccharides in class E Thy-1-negative mutant lymphomas.

10. Polysaccharide biosynthesis in Acetobacter xylinum. Enzymatic synthesis of lipid diphosphate and monophospate sugars.

1. Transfer of oligosaccharide from oligosaccharide pyrophosphoryl dolichol to endogenous acceptor proteins in human breast malignant and normal tissues.