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Literature DB >> 4007130

Transfer of oligosaccharide from oligosaccharide pyrophosphoryl dolichol to endogenous acceptor proteins in human breast malignant and normal tissues.

Abstract

We have prepared dolichylpyrophosphoryl-[14C]-oligosaccharide (Dol-PP-oligosaccharide) from calf thyroid. Microsomal fractions from human breast tissues catalyzed the transfer of labeled oligosaccharide to endogenous acceptor proteins. Malignant tumors showed higher activity of the oligosaccharide transferring enzyme than normal tissue. With kojibiose (Kj), an inhibitor of (Glc3)-glucosidase, an increase in the radioactivity associated with glycoprotein was observed.

Entities: Chemical Disease Species

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Year: 1985 PMID： 4007130 DOI： 10.1007/bf01970017

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

12 in total

1. Detection in human breast carcinomas of an antigen immunologically related to a group-specific antigen of mouse mammary tumor virus.

Authors: R Mesa-Tejada; I Keydar; M Ramanarayanan; T Ohno; C Fenoglio; S Spiegelman
Journal: Proc Natl Acad Sci U S A Date: 1978-03 Impact factor: 11.205

2. Microsomal glucosidases acting on the saccharide moiety of the glucose-containing dolichyl diphosphate oligosaccharide.

Authors: R A Ugalde; R J Staneloni; L F Leloir
Journal: Biochem Biophys Res Commun Date: 1979-12-14 Impact factor: 3.575

3. Increase in the lipid intermediate pathway of protein glycosylation during hen oviduct differentiation.

Authors: J J Lucas; E Levin
Journal: J Biol Chem Date: 1977-06-25 Impact factor: 5.157

Review 4. Synthesis and processing of asparagine-linked oligosaccharides.

Authors: S C Hubbard; R J Ivatt
Journal: Annu Rev Biochem Date: 1981 Impact factor: 23.643

5. Lipid-saccharide intermediates in glycoprotein biosynthesis. I. Formation of an oligosaccharide-lipid by thyroid slices and evaluation of its role in protein glycosylation.

Authors: M J Spiro; R G Spiro; V D Bhoyroo
Journal: J Biol Chem Date: 1976-10-25 Impact factor: 5.157

6. Lipid-bound sugars in malignant human breast tumors. Partial characterization of mannosyl and glucosyl transferase activities.

Authors: A R Santa Cruz; L A Quesada Allue; A Baldi
Journal: Mol Cell Biochem Date: 1983 Impact factor: 3.396

Transfer of oligosaccharide from oligosaccharide pyrophosphoryl dolichol to endogenous acceptor proteins in human breast malignant and normal tissues.

1. Detection in human breast carcinomas of an antigen immunologically related to a group-specific antigen of mouse mammary tumor virus.

2. Microsomal glucosidases acting on the saccharide moiety of the glucose-containing dolichyl diphosphate oligosaccharide.

3. Increase in the lipid intermediate pathway of protein glycosylation during hen oviduct differentiation.

Review 4. Synthesis and processing of asparagine-linked oligosaccharides.

5. Lipid-saccharide intermediates in glycoprotein biosynthesis. I. Formation of an oligosaccharide-lipid by thyroid slices and evaluation of its role in protein glycosylation.

6. Lipid-bound sugars in malignant human breast tumors. Partial characterization of mannosyl and glucosyl transferase activities.

7. Subcellular localization of the sedimentable form of mammary tumor glycoprotein to the tumor cell plasmalemma.

8. Lipid-bound oligosaccharides in insects.

9. Microsomal glucosidases of rat liver. Partial purification and inhibition by disaccharides.

Review 10. The biosynthetic pathway of the asparagine-linked oligosaccharides of glycoproteins.

1. The role of vitamin A in the glycosylation reactions of glycoprotein synthesis in an 'in vitro' system.