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Literature DB >> 6195356

Leupeptin inhibits retrovirus infection in mouse fibroblasts.

Abstract

The protease inhibitor leupeptin was shown to inhibit retrovirus infection in mouse fibroblasts at a step shortly after internalization of the virus particles. The inhibited step most likely was the passage of virus particles through the lysosomes or other acid vesicles. Leupeptin was also shown to inhibit degradation of virus particles in the lysosomes. The results are discussed with respect to the involvement of proteases in the infectious route.

Entities: Chemical Disease Species

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Year: 1983 PMID： 6195356 PMCID： PMC255408

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

12 in total

1. A plaque assay for murine leukemia virus using enzyme-coupled antibodies.

Authors: B A Nexo
Journal: Virology Date: 1977-04 Impact factor: 3.616

2. Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin.

Authors: P O Seglen; B Grinde; A E Solheim
Journal: Eur J Biochem Date: 1979-04-02

3. Effect of protease inhibitors of actinomycetes on lysosomal peptide-hydrolases from swine liver.

Authors: H Ikezawa; T Aoyagi; T Takeuchi; H Umezawa
Journal: J Antibiot (Tokyo) Date: 1971-07 Impact factor: 2.649

4. Novel leukaemogenic retroviruses isolated from cell line derived from spontaneous AKR tumour.

Authors: F S Pedersen; R L Crowther; D Y Tenney; A M Reimold; W A Haseltine
Journal: Nature Date: 1981-07-09 Impact factor: 49.962

5. Protease inhibitors modify induction of endogenous type C oncornavirus.

Authors: K B Hellman; P P Brewer; D R Twardzik; A Hellman
Journal: Proc Soc Exp Biol Med Date: 1981-01

6. Haemagglutinin of influenza virus expressed from a cloned gene promotes membrane fusion.

Authors: J White; A Helenius; M J Gething
Journal: Nature Date: 1982-12-16 Impact factor: 49.962

7. Effects of protease inhibitors on chemical induction of type C virus.

Authors: C W Long; J A Bruszewski; W L Christensen; W A Suk
Journal: Cancer Res Date: 1979-08 Impact factor: 12.701

8. Entry of murine retrovirus into mouse fibroblasts.

Authors: K B Andersen; B A Nexø
Journal: Virology Date: 1983-02 Impact factor: 3.616

9. Synthesis of viral DNA in the cytoplasm of duck embryo fibroblasts and in enucleated cells after infection by avian sarcoma virus.

Authors: H E Varmus; R V Guntaka; W J Fan; S Heasley; J M Bishop
Journal: Proc Natl Acad Sci U S A Date: 1974-10 Impact factor: 11.205

10. Fusion of Semliki forest virus with the plasma membrane can be induced by low pH.

Authors: J White; J Kartenbeck; A Helenius
Journal: J Cell Biol Date: 1980-10 Impact factor: 10.539

7 in total

1. Nanomolar concentrations of Bowman-Birk soybean protease inhibitor suppress x-ray-induced transformation in vitro.

Authors: J Yavelow; M Collins; Y Birk; W Troll; A R Kennedy
Journal: Proc Natl Acad Sci U S A Date: 1985-08 Impact factor: 11.205

2. Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and 2 and by Simian immunodeficiency virus.

Authors: P R Clapham; D Blanc; R A Weiss
Journal: Virology Date: 1991-04 Impact factor: 3.616

3. Protease inhibitors suppress the in vitro and in vivo replication of rotavirus.

Authors: S L Vonderfecht; R L Miskuff; S B Wee; S Sato; R R Tidwell; J D Geratz; R H Yolken
Journal: J Clin Invest Date: 1988-12 Impact factor: 14.808

4. Factors involved in entry of the human immunodeficiency virus type 1 into permissive cells: lack of evidence of a role for CD26.

Authors: I Lazaro; D Naniche; N Signoret; A M Bernard; D Marguet; D Klatzmann; T Dragic; M Alizon; Q Sattentau
Journal: J Virol Date: 1994-10 Impact factor: 5.103