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Literature DB >> 2429615

Alphavirus replication in cultured cells and infected animals is inhibited by antiproteinase agents.

O P Zhirnov, A V Ovcharenko, E E Melnikova, A G Bukrinskaya.

Abstract

The influence of different antiproteinase agents on alphavirus replication was examined. Sindbis virus multicycle replication in cultured cells was suppressed by N-tosyl-phenylalanine chloromethyl ketone (TPCK), an inhibitor of chymotrypsin-like proteinases, and by aprotinin, an inhibitor of a wide spectrum of proteinases. Antiviral activity of TPCK was also demonstrated in Sindbis virus-infected animals. Parenteral injections of TPCK in infected mice reduced virus titers in brain and blood. The possible mechanism(s) of antiviral action of the antiproteinase agents are discussed.

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Year: 1986 PMID： 2429615 PMCID： PMC7134154 DOI： 10.1016/0166-3542(86)90021-5

Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970

27 in total

1. Direct evidence for the presence of histidine in the active center of chymotrypsin.

Authors: G SCHOELLMANN; E SHAW
Journal: Biochemistry Date: 1963 Mar-Apr Impact factor: 3.162

2. Inhibition of fibrinolytic and thromboplastic activity by Trasylol.

Authors: C J Amris
Journal: Scand J Haematol Date: 1966

3. Structure and assembly of alphaviruses.

Authors: H Garoff; C Kondor-Koch; H Riedel
Journal: Curr Top Microbiol Immunol Date: 1982 Impact factor: 4.291

Review 4. [The phenomenon of proteolytic activation of myxoviruses and a new strategy for treating viral diseases].

Authors: O P Zhirnov
Journal: Vopr Virusol Date: 1983 Jul-Aug

5. Mx-dependent resistance to influenza viruses is induced by mouse interferons alpha and beta but not gamma.

Authors: P Staeheli; M A Horisberger; O Haller
Journal: Virology Date: 1984-01-30 Impact factor: 3.616

6. Host-dependent variation of asparagine-linked oligosaccharides at individual glycosylation sites of Sindbis virus glycoproteins.

Authors: P Hsieh; M R Rosner; P W Robbins
Journal: J Biol Chem Date: 1983-02-25 Impact factor: 5.157

1. Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2.

Authors: D Grandgirard; E Studer; L Monney; T Belser; I Fellay; C Borner; M R Michel
Journal: EMBO J Date: 1998-08-10 Impact factor: 11.598

1 in total

Alphavirus replication in cultured cells and infected animals is inhibited by antiproteinase agents.

1. Direct evidence for the presence of histidine in the active center of chymotrypsin.

2. Inhibition of fibrinolytic and thromboplastic activity by Trasylol.

3. Structure and assembly of alphaviruses.

Review 4. [The phenomenon of proteolytic activation of myxoviruses and a new strategy for treating viral diseases].

5. Mx-dependent resistance to influenza viruses is induced by mouse interferons alpha and beta but not gamma.

6. Host-dependent variation of asparagine-linked oligosaccharides at individual glycosylation sites of Sindbis virus glycoproteins.

7. Oligopeptides that specifically inhibit membrane fusion by paramyxoviruses: studies on the site of action.

8. Suppression of influenza virus replication in infected mice by protease inhibitors.

9. Diabetes responsive to intravenous but not subcutaneous insulin: effectiveness of aprotinin.

10. Proteolytic activation of influenza WSN virus in cultured cells is performed by homologous plasma enzymes.

1. Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2.