Literature DB >> 6194836

Sickle cell-beta +-thalassaemia: a haematological and clinical study in Liberia.

U Bienzle, R Kappes, A Reimer, M Feldheim, F W Tischendorf, E Kohne.   

Abstract

Clinical and haematological features of 20 patients of several Liberian ethnic groups with sickle cell-beta +-thalassaemia are reported. Haemoglobin analysis showed increased Hb A2 values, high Hb A levels (median 25%), variable amounts of Hb F and a slight imbalance of non alpha/alpha globin chain synthesis ratios. The clinical and other haematological findings varied but the disease seems to run a relatively mild course in the majority of the patients.

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Year:  1983        PMID： 6194836     DOI： 10.1007/bf00319897

Source DB:  PubMed          Journal:  Blut        ISSN： 0006-5242


  14 in total

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Authors:  M C Willcox; D J Weatherall; J B Clegg
Journal:  J Med Genet       Date:  1975-06       Impact factor: 6.318

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Authors:  A MONTI; C FELDHAKE; S O SCHWARTZ
Journal:  Ann N Y Acad Sci       Date:  1964-10-07       Impact factor: 5.691

3.  The frequency of elevations in the A and fetal hemoglobin fractions in the natives of Liberia and adjacent regions, with data on haptoglobin and transferrin types.

Authors:  J V NEEL; A R ROBINSON; W W ZUELZER; F B LIVINGSTONE; H E SUTTON
Journal:  Am J Hum Genet       Date:  1961-06       Impact factor: 11.025

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Authors:  K BETKE; H R MARTI; I SCHLICHT
Journal:  Nature       Date:  1959-12-12       Impact factor: 49.962

5.  Genetics of red cells and susceptibility to malaria.

Authors:  L Luzzatto
Journal:  Blood       Date:  1979-11       Impact factor: 22.113

6.  Globin synthesis in the Jamaican Negro with beta-thalassaemia.

Authors:  S Friedman; E Schwartz; V Ahern; E Ahern
Journal:  Br J Haematol       Date:  1974-12       Impact factor: 6.998

7.  The clinical features of sickle-cell- thalassaemia in Jamaica.

Authors:  G R Serjeant; M T Ashcroft; B E Serjeant; P F Milner
Journal:  Br J Haematol       Date:  1973-01       Impact factor: 6.998

8.  The thalassaemia syndromes in Nigeria.

Authors:  G J Esan
Journal:  Br J Haematol       Date:  1970-07       Impact factor: 6.998

9.  Haemoglobin variants, beta-thalassaemia and G-6-PD types in Liberia.

Authors:  M C Willcox; L Beckman
Journal:  Hum Hered       Date:  1981       Impact factor: 0.444

10.  Genetic and biochemical heterogeneity of beta-thalassaemia in Naples.

Authors:  G Pepe; L Lupi; L Luzzatto
Journal:  Br J Haematol       Date:  1980-07       Impact factor: 6.998
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  2 in total

1.  Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the Mediterranean.

Authors:  Bridget S Penman; Oliver G Pybus; David J Weatherall; Sunetra Gupta
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-01       Impact factor: 11.205

2.  The distribution and interaction of haemoglobin variants and the beta thalassaemia gene in Liberia.

Authors:  U Bienzle; H Komp; M Feldheim; A Reimer; E Steffen; I Guggenmoos-Holzmann
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132
  2 in total

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