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Literature DB >> 6193520

RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatibility complex.

M Kronenberg, M Steinmetz, J Kobori, E Kraig, J A Kapp, C W Pierce, C M Sorensen, G Suzuki, T Tada, L Hood.

Abstract

The I-J subregion of the mouse major histocompatibility complex has been reported to encode antigenic determinants expressed by suppressor T cells. Previously, cosmid clones were obtained from mouse sperm DNA that contain all of the sequences between the I-A and I-E subregions, where I-J has been mapped genetically. However, hybridization of these sequences to RNA prepared from several I-J-positive suppressor T-cell hybridomas did not reveal the presence of a transcript. In addition, no rearrangements in this DNA were detected in the suppressor T cells that we have analyzed. Our results indicate that the I-J polypeptides are not encoded between the I-A and I-E subregions of the major histocompatibility complex. We discuss several hypotheses concerning the possible location and expression of I-J genes.

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Substances：
RNA

Year: 1983 PMID： 6193520 PMCID： PMC384327 DOI： 10.1073/pnas.80.18.5704

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

30 in total

1. Tissue distribution of I region-associated antigens in the mouse.

Authors: V Hauptfeld; M Hauptfeld; J Klein
Journal: J Immunol Date: 1974-07 Impact factor: 5.422

2. Cell-free translation of a biologically active, antigen-specific suppressor T cell factor.

Authors: K J Wieder; B A Araneo; J A Kapp; D R Webb
Journal: Proc Natl Acad Sci U S A Date: 1982-06 Impact factor: 11.205

3. Reconstitution of antigen-specific suppressor activity with translation products of mRNA.

Authors: M Taniguchi; T Tokuhisa; M Kanno; Y Yaoita; A Shimizu; T Honjo
Journal: Nature Date: 1982-07-08 Impact factor: 49.962

4. A molecular map of the immune response region from the major histocompatibility complex of the mouse.

Authors: M Steinmetz; K Minard; S Horvath; J McNicholas; J Srelinger; C Wake; E Long; B Mach; L Hood
Journal: Nature Date: 1982-11-04 Impact factor: 49.962

5. Isolation of cDNA clones encoding HLA-DR alpha chains.

Authors: C T Wake; E O Long; M Strubin; N Gross; R Accolla; S Carrel; B Mach
Journal: Proc Natl Acad Sci U S A Date: 1982-11 Impact factor: 11.205

6. Expression of cell surface antigens by suppressor T cell hybridomas. I. Comparison of phenotype and function.

Authors: J Trial; J A Kapp; C W Pierce; D C Shreffler; C M Sorensen; C Waltenbaugh
Journal: J Immunol Date: 1983-02 Impact factor: 5.422

7. A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.

Authors: D B Murphy; L A Herzenberg; K Okumura; L A Herzenberg; H O McDevitt
Journal: J Exp Med Date: 1976-09-01 Impact factor: 14.307

8. Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.

Authors: T Tada; M Taniguchi; C S David
Journal: J Exp Med Date: 1976-09-01 Impact factor: 14.307

9. T and B cells that recognize the same antigen do not transcribe similar heavy chain variable region gene segments.

Authors: E Kraig; M Kronenberg; J A Kapp; C W Pierce; A F Abruzzini; C M Sorensen; L E Samelson; R H Schwartz; L E Hood
Journal: J Exp Med Date: 1983-07-01 Impact factor: 14.307

10. Antigen-specific suppression in genetic responder mice to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). Characterization of conventional and hybridoma-derived factors produced by suppressor T cells from mice injected as neonates with syngeneic GAT macrophages.

Authors: C M Sorensen; C W Pierce
Journal: J Exp Med Date: 1982-12-01 Impact factor: 14.307

45 in total

1. The I-J-disparate mouse strains B10.A(3R) and B10.A(5R) have identical E beta sequences.

Authors: J Gorski; C E Hayes
Journal: Immunogenetics Date: 1990 Impact factor: 2.846

Review 2. Immune profiling and cancer post transplantation.

Authors: Christopher Martin Hope; Patrick Toby H Coates; Robert Peter Carroll
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Review 3. Special regulatory T-cell review: Suppressors regulated but unsuppressed.

Authors: Judith A Kapp
Journal: Immunology Date: 2008-01 Impact factor: 7.397

Review 4. Special regulatory T-cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm.

Authors: Ronald N Germain
Journal: Immunology Date: 2008-01 Impact factor: 7.397

10. Involvement of I-J epitopes in the self- and allo-recognition sites of T cells: blocking of syngeneic and allogeneic mixed lymphocyte reaction-responder cells by monoclonal anti-I-J antibodies.

Authors: W Uracz; R Abe; T Tada
Journal: Proc Natl Acad Sci U S A Date: 1985-05 Impact factor: 11.205