Literature DB >> 6187827

Characteristics of a shared idiotype by two IgM anti-herpes simplex virus monoclonal antibodies that recognize different determinants.

R C Kennedy, K Adler-Storthz, R D Henkel, G R Dreesman.   

Abstract

Two IgM monoclonal antibodies (McAb) that recognized distinct antigenic determinants of herpes simplex virus type 2 (HSV2) were shown to share idiotypes. Seven other IgM McAb generated to either HSV2 or the major envelope glycoprotein of HSV2, VP119, did not express this shared idiotype. The idiotypic determinants were associated with the antibody-combining site, because HSV2 inhibited the idiotype-anti-idiotype reactions. Anti-HSV2 sera raised in BALB/c mice also expressed the idiotype shared by the two anti-HSV2 McAb.

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Year:  1983        PMID： 6187827

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  8 in total

Review 1.  Monoclonal antibodies: implications for virology. Brief review.

Authors:  K C McCullough
Journal:  Arch Virol       Date:  1986       Impact factor: 2.574

Review 2.  Monoclonal antibodies against microorganisms.

Authors:  R A Polin
Journal:  Eur J Clin Microbiol       Date:  1984-10       Impact factor: 3.267

3.  Production and characterization of an anti-idiotypic antibody specific for a monoclonal antibody to glycoprotein D of herpes simplex virus.

Authors:  J L Lathey; B T Rouse; D E Wiley; R J Courtney
Journal:  Immunology       Date:  1986-01       Impact factor: 7.397

4.  Biotin-avidin-amplified enzyme immunoassay for detection of herpes simplex virus antigen in clinical specimens.

Authors:  K Adler-Storthz; C Kendall; R C Kennedy; R D Henkel; G R Dreesman
Journal:  J Clin Microbiol       Date:  1983-12       Impact factor: 5.948

5.  Anti-idiotypic antibody as potential serodiagnostic reagent for detection of bluetongue virus infection.

Authors:  E M Zhou; W Huang
Journal:  J Clin Microbiol       Date:  1995-04       Impact factor: 5.948

6.  Antiidiotype modulation of herpes simplex virus infection leading to increased pathogenicity.

Authors:  R C Kennedy; K Adler-Storthz; J W Burns; R D Henkel; G R Dreesman
Journal:  J Virol       Date:  1984-06       Impact factor: 5.103

7.  Suppression of in vivo tumor formation induced by simian virus 40-transformed cells in mice receiving antiidiotypic antibodies.

Authors:  R C Kennedy; G R Dreesman; J S Butel; R E Lanford
Journal:  J Exp Med       Date:  1985-06-01       Impact factor: 14.307

8.  Enhancement of the immune response to hepatitis B surface antigen. In vivo administration of antiidiotype induces anti-HBs that expresses a similar idiotype.

Authors:  R C Kennedy; G R Dreesman
Journal:  J Exp Med       Date:  1984-03-01       Impact factor: 14.307
  8 in total

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