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Literature DB >> 6607967

Enhancement of the immune response to hepatitis B surface antigen. In vivo administration of antiidiotype induces anti-HBs that expresses a similar idiotype.

Abstract

BALB/c mice receiving antiidiotype antibodies before the injection of hepatitis B surface antigen (HBsAg) generated an enhanced anti-HBs response. Mice given antiidiotype antibodies in a soluble form induced predominantly IgM anti-HBs, whereas alum-precipitated antiidiotype produced primarily IgG anti-HBs. Injection of antiidiotype antibodies alone induced anti-HBs that inhibited a common interspecies anti-HBs idiotype-antiidiotype reaction and recognized the group-specific determinant of HBsAg. These data support the view that antiidiotype antibodies may modulate the immune response to an infectious viral agent.

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Year: 1984 PMID： 6607967 PMCID： PMC2187246 DOI： 10.1084/jem.159.3.655

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

32 in total

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Authors: R C Kennedy; G R Dreesman
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27 in total

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