Literature DB >> 6184485

Protease bypass of temperature-sensitive murine leukemia virus maturation mutants.

P Traktman, D Baltimore.   

Abstract

Cells infected with certain temperature-sensitive mutants of Moloney murine leukemia virus synthesize the virion precursor proteins but neither bud virions nor cleave precursor proteins to their mature form. Addition of proteases to cells infected with these mutants caused cleavage of the precursor proteins Pr65gag and Pr180gag-pol to their mature forms at the nonpermissive temperature. Concomitantly there was release from the cells of morphologically normal virions. The enzymatically inactive Pr180gag-pol was cleaved to active reverse transcriptase (p85), which was found in the released particles. External protease treatment apparently bypassed the lesion in these viral mutants, suggesting that their defect may involve a virus-specific protease.

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Year:  1982        PMID： 6184485      PMCID： PMC256364     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  21 in total

1.  Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.

Authors:  S W Kessler
Journal:  J Immunol       Date:  1975-12       Impact factor: 5.422

2.  Dependence of Moloney murine leukemia virus production on cell growth.

Authors:  M P Paskind; R A Weinberg; D Baltimore
Journal:  Virology       Date:  1975-09       Impact factor: 3.616

3.  Studies on the budding process of a temperature-sensitive mutant of murine leukemia virus with a scanning electron microscope.

Authors:  P K Wong; R MacLeod
Journal:  J Virol       Date:  1975-08       Impact factor: 5.103

4.  Cleavage of Rous sarcoma viral polypeptide precursor into internal structural proteins in vitro involves viral protein p15.

Authors:  K von der Helm
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

5.  Defective cleavage of a precursor polypeptide in a temperature-sensitive mutant of avian sarcoma virus.

Authors:  J M Rohrschneider; H Diggelmann; H Ogura; R R Friis; H Bauer
Journal:  Virology       Date:  1976-11       Impact factor: 3.616

6.  Studies of two temperature-sensitive mutants of Moloney murine leukemia virus.

Authors:  P K Wong; J A McCarter
Journal:  Virology       Date:  1974-04       Impact factor: 3.616

7.  Characterization of temperature-sensitive mutants of murine leukemia virus.

Authors:  J R Stephenson; S A Aaronson
Journal:  Virology       Date:  1973-07       Impact factor: 3.616

8.  A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.

Authors:  W M Bonner; R A Laskey
Journal:  Eur J Biochem       Date:  1974-07-01

9.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

10.  Plaque assay techniques for murine leukemia viruses.

Authors:  W P Rowe; W E Pugh; J W Hartley
Journal:  Virology       Date:  1970-12       Impact factor: 3.616
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  8 in total

1.  Molecular genetic analysis of a vaccinia virus gene with an essential role in DNA replication.

Authors:  E Evans; P Traktman
Journal:  J Virol       Date:  1987-10       Impact factor: 5.103

2.  Sequences near the 5' long terminal repeat of avian leukosis viruses determine the ability to induce osteopetrosis.

Authors:  H L Robinson; S S Reinsch; P R Shank
Journal:  J Virol       Date:  1986-07       Impact factor: 5.103

3.  A deletion mutation in the 5' part of the pol gene of Moloney murine leukemia virus blocks proteolytic processing of the gag and pol polyproteins.

Authors:  S Crawford; S P Goff
Journal:  J Virol       Date:  1985-03       Impact factor: 5.103

4.  Deletion mutants of Moloney murine leukemia virus which lack glycosylated gag protein are replication competent.

Authors:  P Schwartzberg; J Colicelli; S P Goff
Journal:  J Virol       Date:  1983-05       Impact factor: 5.103

5.  Regulation of Moloney murine leukemia virus replication in chronically infected cells arrested at the G0/G1 phase.

Authors:  I Gloger; G Arad; A Panet
Journal:  J Virol       Date:  1985-06       Impact factor: 5.103

6.  Mutations in the gag gene of Moloney murine leukemia virus: effects on production of virions and reverse transcriptase.

Authors:  P Schwartzberg; J Colicelli; M L Gordon; S P Goff
Journal:  J Virol       Date:  1984-03       Impact factor: 5.103

7.  The reverse transcriptase gene of cauliflower mosaic virus is translated separately from the capsid gene.

Authors:  M Schultze; T Hohn; J Jiricny
Journal:  EMBO J       Date:  1990-04       Impact factor: 11.598

8.  Import of rat ornithine transcarbamylase precursor into mitochondria: two-step processing of the leader peptide.

Authors:  E S Sztul; J P Hendrick; J P Kraus; D Wall; F Kalousek; L E Rosenberg
Journal:  J Cell Biol       Date:  1987-12       Impact factor: 10.539
  8 in total

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