Literature DB >> 6183379

MOlecular cloning of human alpha and beta interferon genes from Namalwa cells.

E Dworkin-Rastl, M B Dworkin, P Swetly.   

Abstract

A cDNA library constructed from poly(A)+RNA of Sendai virus-induced human lymphoblastoid (Namalwa) cells was screened with a synthetic oligonucleotide specific for interferon genes. Recombinant plasmids containing sequences derived from alpha and beta interferon (IFN) mRNAs were obtained. The clones were characterized by RNA transfer hybridization, translation of hybrid-isolated RNA, and DNA sequencing. One alpha interferon (IFN-alpha) clone obtained is a variant differing from previously described clones in the location of its polyadenylation site.

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Year:  1982        PMID： 6183379     DOI： 10.1089/jir.1982.2.575

Source DB:  PubMed          Journal:  J Interferon Res        ISSN： 0197-8357


  5 in total

1.  Natural human interferon-alpha 2 is O-glycosylated.

Authors:  G R Adolf; I Kalsner; H Ahorn; I Maurer-Fogy; K Cantell
Journal:  Biochem J       Date:  1991-06-01       Impact factor: 3.857

2.  Polymorphism in the interferon-alpha gene family.

Authors:  I Golovleva; M Kandefer-Szerszen; L Beckman; E Lundgren
Journal:  Am J Hum Genet       Date:  1996-09       Impact factor: 11.025

3.  Low incidence of antibody formation due to long-term interferon-alpha 2c treatment of cancer patients.

Authors:  G G Steinmann; B Göd; F Rosenkaimer; G Adolf; G Bidlingmaier; B Frühbeis; H Lamche; J Lindner; E Patzelt; C Schmähling
Journal:  Clin Investig       Date:  1992-02

4.  A novel class of human type I interferons.

Authors:  R Hauptmann; P Swetly
Journal:  Nucleic Acids Res       Date:  1985-07-11       Impact factor: 16.971

5.  Sensitivity of ortho- and paramyxovirus replication to human interferon alpha.

Authors:  M Strube; G Bodo; C Jungwirth
Journal:  Mol Biol Rep       Date:  1985-10       Impact factor: 2.316
  5 in total

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