Literature DB >> 6183198

Association of PLT specificity of alloreactive lymphocyte clones with HLA-DR, MB and MT determinants.

A Zeevi, C Scheffel, K Annen, G Bass, M Marrari, R J Duquesnoy.   

Abstract

The HLA-D region encodes for several serologically defined systems, including DR, MB, and MT. The antigens of MB and MT are strongly associated with two or more DR specificities. The purpose of this study was to determine the role of MB and MT antigens in lymphocyte alloactivation. A soft agar colony assay was used to generate alloreactive lymphocyte clones primed in mixed leukocyte culture against a stimulator who typed as HLA-DR4,-;MB3,-;MT3,-. In secondary primed lymphocyte typing (PLT) assays, several clones were identified with PLT specificities strongly associated with DR4, MB3, or MT3. The data suggest that HLA-D controls different lymphocyte-activating determinants associated with the serologically defined DR, MB, or MT antigens.

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Year:  1982        PMID： 6183198     DOI： 10.1007/bf00343310

Source DB:  PubMed          Journal:  Immunogenetics        ISSN： 0093-7711            Impact factor:   2.846


  25 in total

1.  Heterogeneity of HLA defined in PLT: a cellular assay detects differences not seen using HLA-DRw serology.

Authors:  K S Zier; B Gänsbacher; S Scholz; E D Albert
Journal:  Immunogenetics       Date:  1980       Impact factor: 2.846

2.  Population genetics of the MLC response: typing for MLC determinants using homozygous and heterozygous reference cells.

Authors:  W Mempel; H Grosse-Wilde; P Baumann; B Netzel; I Steinbauer-Rosenthal; S Scholz; J Bertrams; E D Albert
Journal:  Transplant Proc       Date:  1973-12       Impact factor: 1.066

3.  Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system.

Authors:  M L Markert; P Cresswell
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205

4.  Restimulation properties of cloned alloactivated lymphocytes: detection of a novel type of HLA-D/DR region determinant and allelic subtypes for HLA-Dw3 using cloned reagents.

Authors:  G Pawelec; A Rehbein; P Kahle; C Müller; P Wernet
Journal:  Hum Immunol       Date:  1981-07       Impact factor: 2.850

5.  Dissociation of HLA-D and HLA-DR using primed LD typing.

Authors:  R J Hartzman; F Pappas; P J Romano; A H Johnson; F E Ward; D B Amos
Journal:  Transplant Proc       Date:  1978-12       Impact factor: 1.066

6.  Heterogeneity of cytolytic and suppressor clones of alloactivated cells generated from soft agar colonies.

Authors:  A Zeevi; K M Chiu; R J Duquesnoy
Journal:  Hum Immunol       Date:  1982-10       Impact factor: 2.850

7.  HL-A LD (lymphocyte defined) typing: a rapid assay with primed lymphocytes.

Authors:  M J Sheehy; P M Sondel; M L Bach; R Wank; F H Bach
Journal:  Science       Date:  1975-06-27       Impact factor: 47.728

8.  Expansion of human lymphocyte populations expressing specific immune reactivities. III. Specific colonies, either cytotoxic or proliferative, obtained from a population of responder cells primed in vitro. Preliminary immunogenetic analysis.

Authors:  B Malissen; D Charmot; C Mawas
Journal:  Hum Immunol       Date:  1981-02       Impact factor: 2.850

9.  Human Ia-like DRw lymphocyte antigens stimulating activity in primary mixed lymphocyte reaction.

Authors:  D Fradelizi; A Nunez-Roldan; M Sasportes
Journal:  Eur J Immunol       Date:  1978-02       Impact factor: 5.532

10.  Evidence for a new segregant series of B cell antigens that are encoded in the HLA-D region and that stimulate secondary allogenic proliferative and cytotoxic responses.

Authors:  S Shaw; A H Johnson; G M Shearer
Journal:  J Exp Med       Date:  1980-09-01       Impact factor: 14.307
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  13 in total

1.  Recognition of class II molecules by human T cells. I. Analysis of epitopes of DR and DQ molecules in a DRw11, DRw52, DQw3 haplotype.

Authors:  L K Myers; E J Ball; G Nuñez; P Stastny
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

2.  Defective antigen presentation and novel structural properties of DR1 from an HLA haplotype associated with 21-hydroxylase deficiency.

Authors:  J E Davis; R R Rich; M Van; H V Le; M S Pollack; R G Cook
Journal:  J Clin Invest       Date:  1987-10       Impact factor: 14.808

3.  Functional characterization of infiltrating T lymphocytes in human hepatic allografts.

Authors:  J J Fung; A Zeevi; T E Starzl; J Demetris; S Iwatsuki; R J Duquesnoy
Journal:  Hum Immunol       Date:  1986-06       Impact factor: 2.850

4.  Human allospecific TLCs generated against HLA antigens associated with DR1 through DRw8. III. Family segregation analyses.

Authors:  S Rosen-Bronson; A H Johnson; R J Hartzman; D D Eckels
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

5.  Primed lymphocyte testing specificity of alloreactive lymphocyte clones for HLA-B locus determinants.

Authors:  A Zeevi; C Scheffel; K Annen; R J Duquesnoy
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

6.  Homogeneity of the HLA-linked SB2 and SB3 specificities demonstrated by cloned alloreactive T cells.

Authors:  G Pawelec; S Shaw; M Schneider; A Rehbein; P Wernet
Journal:  Immunogenetics       Date:  1983       Impact factor: 2.846

7.  Detection of HLA-DR associated PLT determinants by alloreactive lymphocyte clones.

Authors:  A Zeevi; K Annen; C Scheffel; R J Duquesnoy
Journal:  Immunogenetics       Date:  1983       Impact factor: 2.846

8.  Origin of lymph node-derived lymphocytes in human hepatic allografts.

Authors:  John J Fung; Adriane Zeevi; A Jake Demetris; Thomas E Starzl; Bernd Markus; Kangnian Chen; Marilyn Marrarri; Rene J Duquesnoy
Journal:  Clin Transpl       Date:  1989

9.  Class II MHC antigen expression in the atherosclerotic plaque: smooth muscle cells express HLA-DR, HLA-DQ and the invariant gamma chain.

Authors:  G K Hansson; L Jonasson; J Holm; L Claesson-Welsh
Journal:  Clin Exp Immunol       Date:  1986-05       Impact factor: 4.330

10.  An HLA-DR negative acute leukaemia which stimulates MLC and CMC responses.

Authors:  G M Taylor; W Fergusson; P A Dyer; R Harris; G Morrell
Journal:  Cancer Immunol Immunother       Date:  1983       Impact factor: 6.968
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