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Literature DB >> 14186462

SUBCLASSES OF HUMAN GAMMA-2-GLOBULIN BASED ON DIFFERENCES IN THE HEAVY POLYPEPTIDE CHAINS.

Abstract

Three subclasses of human gamma(2)-globulin (IgG) molecules were detected in normal human serum with antiserums prepared in monkeys. These subclasses, designated gamma(2a)-, gamma(2b)-, and gamma(2c)-globulins, have antibody activity. The distinguishing antigenic characteristics of each subclass were associated with the heavy polypeptide chains and the F (fast) fragments resulting from treatment of gamma(2)-globulins with papain.

Entities: Species

Keywords: ANTIGENS; EXPERIMENTAL LAB STUDY; GAMMA GLOBULIN; GEL DIFFUSION TESTS; IMMUNOELECTROPHORESIS; PEPTIDES; PRECIPITIN TESTS

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Year: 1964 PMID： 14186462 DOI： 10.1126/science.146.3642.400

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

72 in total

1. The C-terminal sequences of the heavy chains of human immunoglobulin G myeloma proteins of differing isotopes and allotypes.

Authors: J W Prahl
Journal: Biochem J Date: 1967-12 Impact factor: 3.857

2. Immunogenic and antigenic epitopes of immunoglobulins. XIV. Antigenic variants of IgG4 proteins revealed with monoclonal antibodies.

Authors: M R Walker; P Bird; D O Ulaeto; F Vartdal; D M Goodall; R Jefferis
Journal: Immunology Date: 1986-01 Impact factor: 7.397

3. Correlation of Lyme Disease-Associated IgG4 Autoantibodies With Synovial Pathology in Antibiotic-Refractory Lyme Arthritis.

Authors: Katherine B Sulka; Klemen Strle; Jameson T Crowley; Robert B Lochhead; Robert Anthony; Allen C Steere
Journal: Arthritis Rheumatol Date: 2018-09-24 Impact factor: 10.995

4. Cytokine responses of human blood monocytes stimulated with Igs.

Authors: J L Foreback; D G Remick; E Crockett-Torabi; P A Ward
Journal: Inflammation Date: 1997-10 Impact factor: 4.092

5. Proliferative glomerulonephritis with monoclonal IgG2κ deposit successfully treated with steroids: a case report and review of the literature.

Authors: Ryuji Ohashi; Yukinao Sakai; Tomoyuki Otsuka; Dai Ohno; Yukinari Masuda; Tsuneo Murasawa; Naoki Sato; Akira Shimizu
Journal: CEN Case Rep Date: 2013-02-26

10. Catabolism of human gammaG-immunoglobulins of different heavy chain subclasses. I. Catabolism of gammaG-myeloma proteins in man.

Authors: H L Spiegelberg; B G Fishkin; H M Grey
Journal: J Clin Invest Date: 1968-10 Impact factor: 14.808

SUBCLASSES OF HUMAN GAMMA-2-GLOBULIN BASED ON DIFFERENCES IN THE HEAVY POLYPEPTIDE CHAINS.

1. The C-terminal sequences of the heavy chains of human immunoglobulin G myeloma proteins of differing isotopes and allotypes.

2. Immunogenic and antigenic epitopes of immunoglobulins. XIV. Antigenic variants of IgG4 proteins revealed with monoclonal antibodies.

3. Correlation of Lyme Disease-Associated IgG4 Autoantibodies With Synovial Pathology in Antibiotic-Refractory Lyme Arthritis.

4. Cytokine responses of human blood monocytes stimulated with Igs.

5. Proliferative glomerulonephritis with monoclonal IgG2κ deposit successfully treated with steroids: a case report and review of the literature.

6. Absolute Quantitation of Glycoforms of Two Human IgG Subclasses Using Synthetic Fc Peptides and Glycopeptides.

Review 7. Phagocytic, opsonic and immunoglobulin studies in newborns.

8. Recombination of heavy and light chains from human immunoglobulins.

9. Compleat immunology: science or septophrenia?

10. Catabolism of human gammaG-immunoglobulins of different heavy chain subclasses. I. Catabolism of gammaG-myeloma proteins in man.