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Literature DB >> 6180281

Thymine inhibits suppression by an Escherichia coli nonsense and frameshift suppressor.

Abstract

A mutant strain of Escherichia coli suppressed a frameshift and some UAG, UAA, and UGA mutants of bacteriophage T4 at 37 degrees C but not at 31 degrees C. This suppression was inhibited by the addition of thymine or thymidine to the medium used to test phage growth. Furthermore, the suppressor strain required thymine or thymidine for growth on minimal medium at 43 degrees C and if this auxotrophy was removed by reversion or recombination the strain no longer suppressed. These results suggest a link between thymidine nucleotide biosynthesis and suppression.

Entities: Chemical Species

Mesh：

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Year: 1982 PMID： 6180281 DOI： 10.1007/bf00331852

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

18 in total

1. A frame-shift mutation involving the addition of two base pairs in the lysozyme gene of phage t4.

Authors: Y Okada; E Terzaghi; G Streisinger; J Emrich; M Inouye; A Tsugita
Journal: Proc Natl Acad Sci U S A Date: 1966-12 Impact factor: 11.205

2. The identification of the tRNA substrates for the supK tRNA methylase.

Authors: W T Pope; A Brown; R H Reeves
Journal: Nucleic Acids Res Date: 1978-03 Impact factor: 16.971

Review 3. Mechanisms of suppression.

Authors: P E Hartman; J R Roth
Journal: Adv Genet Date: 1973 Impact factor: 1.944

Review 8. The genome of bacteriophage T4.

Authors: W B Wood; H R Revel
Journal: Bacteriol Rev Date: 1976-12

Thymine inhibits suppression by an Escherichia coli nonsense and frameshift suppressor.

1. A frame-shift mutation involving the addition of two base pairs in the lysozyme gene of phage t4.

2. The identification of the tRNA substrates for the supK tRNA methylase.

Review 3. Mechanisms of suppression.

4. Tryptophan transfer RNA as the UGA suppressor.

5. A ribosomal ambiguity mutation.

6. Mutants in Escherichia coli ribosomes: a new selection.

7. Isolation and characterization of ribonuclease I mutants of Escherichia coli.

Review 8. The genome of bacteriophage T4.

Review 9. Linkage map of Escherichia coli K-12, edition 6.

10. Rapid mapping of conditional and auxotrophic mutations in Escherichia coli K-12.

1. Frameshift suppression by thyA mutants of Escherichia coli K-12.

2. Genetic system for analyzing Escherichia coli thymidylate synthase.

3. Suppression by thymidine-requiring mutants of Escherichia coli K-12.

4. Nonsense suppression in thymine-requiring strains of Escherichia coli is a consequence of altered folate metabolism.