Literature DB >> 6178612

Agonist effects of [D-Pro2,D-Phe7,D-Trp9]substance P--evidence for different receptors.

A B Hawcock, A G Hayes, M B Tyers.   

Abstract

[D-Pro2,D-Phe7,D-Trp9]substance P contracted guinea-pig ileum (GPI) indirectly, probably via substance P (SP) receptors on postganglionic parasympathetic neurones. It also depolarised rat superior cervical ganglion cells and contracted the rabbit external jugular vein, suggesting an agonist action on SP receptors in these tissues. In contrast, it had weak antagonist activity on smooth muscle SP receptors in GPI. This suggests that the receptor in GPI smooth muscle may differ from those in the other tissues.

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Year:  1982        PMID： 6178612     DOI： 10.1016/0014-2999(82)90189-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  10 in total

1.  Differences in neurokinin receptor pharmacology between rat and guinea-pig superior cervical ganglia.

Authors:  G R Seabrook; M Main; B Bowery; N Wood; R G Hill
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

2.  An examination of the pharmacology of two substance P antagonists and the evidence for tachykinin receptor subtypes.

Authors:  S J Bailey; R L Featherstone; C C Jordan; I K Morton
Journal:  Br J Pharmacol       Date:  1986-01       Impact factor: 8.739

3.  International Substance P Symposium. Dublin, April 27-29, 1983. Abstracts.

Authors: 
Journal:  Ir J Med Sci       Date:  1983       Impact factor: 1.568

4.  Plasma protein extravasation induced by mammalian tachykinins in rat skin: influence of anaesthetic agents and an acetylcholine antagonist.

Authors:  R Couture; R Kérouac
Journal:  Br J Pharmacol       Date:  1987-06       Impact factor: 8.739

5.  Pharmacological characterization of a substance P antagonist, [D-Arg1,D-Pro2,D-Trp7,9,Leu11]-substance P.

Authors:  S P Watson
Journal:  Br J Pharmacol       Date:  1983-09       Impact factor: 8.739

6.  Development of a new tachykinin antagonist.

Authors:  R Mathison; P Stofer; F Barja; H Immer
Journal:  Experientia       Date:  1984-01-15

7.  Studies on the trigeminal antidromic vasodilatation and plasma extravasation in the rat.

Authors:  R Couture; A C Cuello
Journal:  J Physiol       Date:  1984-01       Impact factor: 5.182

8.  A tachykinin antagonist inhibits gastric emptying and gastrointestinal transit in the rat.

Authors:  P Holzer; U Holzer-Petsche; S Leander
Journal:  Br J Pharmacol       Date:  1986-11       Impact factor: 8.739

9.  The effect of substance P and related peptides on the guinea-pig lung strip.

Authors:  S E Webber; J C Foreman
Journal:  Agents Actions       Date:  1984-04

10.  A study of [D-Pro2, D-Phe7, D-Trp9]-substance P and [D-Trp7,9]-substance P as tachykinin partial agonists in the rat colon.

Authors:  S J Bailey; C C Jordan
Journal:  Br J Pharmacol       Date:  1984-06       Impact factor: 8.739
  10 in total

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