Literature DB >> 6178414

Effects of flavonoids and transitional metal cations on antigen-induced histamine release from human basophils.

E Middleton, G Drzewiecki.   

Abstract

Structure-activity relationship studies have been performed on the inhibition of antigen-induced histamine release from human basophils by various naturally occurring flavonoids. Quercetin was the most active compound. Of the transitional metal ions, Cu2+ most effectively blocked the inhibitory activity of quercetin, possibly through a chelation mechanism.

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Year:  1982        PMID: 6178414     DOI: 10.1016/0006-2952(82)90044-2

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN: 0006-2952            Impact factor:   5.858


  5 in total

1.  Effect of flavonoids on tumor promoter-induced basophil histamine release and protein kinase C.

Authors:  E Middleton; P Ferriola; G Drzewiecki
Journal:  Trans Am Clin Climatol Assoc       Date:  1989

2.  Effects of silybin on histamine release from human basophil leucocytes.

Authors:  A Miadonna; A Tedeschi; E Leggieri; M Lorini; M Froldi; C Zanussi
Journal:  Br J Clin Pharmacol       Date:  1987-12       Impact factor: 4.335

3.  Kinetics of the inhibitory effect of flavonoids on histamine secretion from mast cells.

Authors:  C Bronner; Y Landry
Journal:  Agents Actions       Date:  1985-04

4.  Flavonoids as inhibitors of rat liver cytosolic glutathione S-transferase.

Authors:  M Merlos; R M Sanchez; J Camarasa; T Adzet
Journal:  Experientia       Date:  1991-06-15

5.  Modulation of the effect of histamine-releasing lymphokine on human basophils.

Authors:  I C Ezeamuzie; E S Assem
Journal:  Agents Actions       Date:  1984-04
  5 in total

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