Literature DB >> 2065760

Flavonoids as inhibitors of rat liver cytosolic glutathione S-transferase.

M Merlos1, R M Sanchez, J Camarasa, T Adzet.   

Abstract

The inhibitory potencies of different flavonoids for rat liver cytosolic glutathione S-transferase activity varied over 30-fold, depending on the pattern of hydroxylation, the presence of a C-2, C-3 double bond and the substitution of a hydroxyl group with a sugar moiety. Kinetic inactivation studies of the enzyme with the inhibitor quercetin revealed a non-competitive profile versus both glutathione and 1-chloro-2,4-dinitrobenzene.

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Year:  1991        PMID： 2065760     DOI： 10.1007/BF01949888

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  23 in total

1.  Structure/activity studies of flavonoids as inhibitors of cyclic AMP phosphodiesterase and relationship to quantum chemical indices.

Authors:  J E Ferrell; P D Chang Sing; G Loew; R King; J M Mansour; T E Mansour
Journal:  Mol Pharmacol       Date:  1979-09       Impact factor: 4.436

2.  Computer-automated structure evaluation of flavonoids and other structurally related compounds as glyoxalase I enzyme inhibitors.

Authors:  G Klopman; M L Dimayuga
Journal:  Mol Pharmacol       Date:  1988-08       Impact factor: 4.436

3.  Inhibition of lens aldose reductase by flavonoids--their possible role in the prevention of diabetic cataracts.

Authors:  S D Varma; J H Kinoshita
Journal:  Biochem Pharmacol       Date:  1976-11-15       Impact factor: 5.858

4.  Effect of flavone inhibitors of transport ATPases on histamine secretion from rat mast cells.

Authors:  C M Fewtrell; B D Gomperts
Journal:  Nature       Date:  1977-02-17       Impact factor: 49.962

5.  On the mechanism of antithrombotic action of flavonoids.

Authors:  R J Gryglewski; R Korbut; J Robak; J Swies
Journal:  Biochem Pharmacol       Date:  1987-02-01       Impact factor: 5.858

6.  Effects of flavonoids and transitional metal cations on antigen-induced histamine release from human basophils.

Authors:  E Middleton; G Drzewiecki
Journal:  Biochem Pharmacol       Date:  1982-04-01       Impact factor: 5.858

7.  Effect of ellagic acid on hepatic and pulmonary xenobiotic metabolism in mice: studies on the mechanism of its anticarcinogenic action.

Authors:  M Das; D R Bickers; H Mukhtar
Journal:  Carcinogenesis       Date:  1985-10       Impact factor: 4.944

Review 8.  Flavonoids, a class of natural products of high pharmacological potency.

Authors:  B Havsteen
Journal:  Biochem Pharmacol       Date:  1983-04-01       Impact factor: 5.858

9.  Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids. A structure-activity study.

Authors:  W F Hodnick; F S Kung; W J Roettger; C W Bohmont; R S Pardini
Journal:  Biochem Pharmacol       Date:  1986-07-15       Impact factor: 5.858

10.  Inhibition of (Na+, K+)adenosine triphosphatase and its partial reactions by quercetin.

Authors:  Y Kuriki; E Racker
Journal:  Biochemistry       Date:  1976-11-16       Impact factor: 3.162
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  3 in total

1.  AN9, a petunia glutathione S-transferase required for anthocyanin sequestration, is a flavonoid-binding protein.

Authors:  L A Mueller; C D Goodman; R A Silady; V Walbot
Journal:  Plant Physiol       Date:  2000-08       Impact factor: 8.340

2.  Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein.

Authors:  G Conseil; H Baubichon-Cortay; G Dayan; J M Jault; D Barron; A Di Pietro
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-18       Impact factor: 11.205

3.  Differential scanning fluorometry signatures as indicators of enzyme inhibitor mode of action: case study of glutathione S-transferase.

Authors:  Wendy A Lea; Anton Simeonov
Journal:  PLoS One       Date:  2012-04-30       Impact factor: 3.240
  3 in total

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