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Literature DB >> 6177629

Serological cross-reactivity between products of separate I regions.

D Birnbaum, M Pla, M Colombani, J Colombani.

Abstract

A B10.S(7R) anti-B10.S(9R) serum (anti-IJEkCd) contained, as expected, antibodies specific for the I-E-subregion-encoded determinant Ia.7. However, tests on recombinant haplotypes demonstrated a series of unexpected weak extrareactions which could be interpreted to be directed against antigenic determinants encoded in the I-A subregion of the H-2 complex. The same type of extrareaction was observed in eluates from I-As, I-Ek cells coated with A.TH anti-A.TL (I-As, I-Ek anti-I-Ak, I-Ek) serum. This reactivity in serum and eluates could be interpreted as cross-reactivity between products of the I-E and I-A subregions.

Entities: Gene

Mesh：

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Year: 1982 PMID： 6177629 DOI： 10.1007/BF00375504

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

15 in total

1. Organization of the immune response genes.

Authors: J W Uhr; J D Capra; E S Vitetta; R G Cook
Journal: Science Date: 1979-10-19 Impact factor: 47.728

2. Chemical characterization of murine Ia alloantigens determined by the i-E/i-C subregions of the H-2 complex.

Authors: J Silver; W A Russell; B L Reis; J A Frelinger
Journal: Proc Natl Acad Sci U S A Date: 1977-11 Impact factor: 11.205

3. Analysis of serologic cross-reactions between human and mouse Ia antigens.

Authors: M Letarte; J Falk
Journal: J Immunol Date: 1980-09 Impact factor: 5.422

4. Detection of CML determinants associated with H-2 controlled E beta and E alpha chains.

Authors: A Juretić; Z A Nagy; J Klein
Journal: Nature Date: 1981-01-22 Impact factor: 49.962

5. Variable synthesis and expression of E alpha and Ae (E beta) Ia polypeptide chains in mice of different H-2 haplotypes.

Authors: P P Jones; D B Murphy; H O McDevitt
Journal: Immunogenetics Date: 1981 Impact factor: 2.846

6. Separation of anti-Ia (I-region associated antigens) from anti-H-2 antibodies in complex sera, by absorption on blood platelets. description of three new Ia specificities.

Authors: J Colombani; M Colombani; D C Shreffler; C David
Journal: Tissue Antigens Date: 1976-02

7. Partial N-terminal amino acid sequence analyses and comparative tryptic peptide maps of murine Ia molecules encoded by the I-A subregion.

Authors: J M Cecka; M Mc Millan; D B Murphy; H O McDevitt; L Hood
Journal: Eur J Immunol Date: 1979-12 Impact factor: 5.532

8. Structural studies of the protein portion of the H-2-linked Ia glycoprotein antigens of the mouse: tryptic peptide comparison of products from the I-A and I-C subregions of B10-HTT.

Authors: J H Freed; C S David; D C Shreffler; S G Nathenson
Journal: J Immunol Date: 1978-07 Impact factor: 5.422

Serological cross-reactivity between products of separate I regions.

1. Organization of the immune response genes.

2. Chemical characterization of murine Ia alloantigens determined by the i-E/i-C subregions of the H-2 complex.

3. Analysis of serologic cross-reactions between human and mouse Ia antigens.

4. Detection of CML determinants associated with H-2 controlled E beta and E alpha chains.

5. Variable synthesis and expression of E alpha and Ae (E beta) Ia polypeptide chains in mice of different H-2 haplotypes.

6. Separation of anti-Ia (I-region associated antigens) from anti-H-2 antibodies in complex sera, by absorption on blood platelets. description of three new Ia specificities.

7. Partial N-terminal amino acid sequence analyses and comparative tryptic peptide maps of murine Ia molecules encoded by the I-A subregion.

8. Structural studies of the protein portion of the H-2-linked Ia glycoprotein antigens of the mouse: tryptic peptide comparison of products from the I-A and I-C subregions of B10-HTT.

9. Two-gene control of the expression of a murine Ia antigen.

10. Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.

1. Fine specificity of a proliferating T-cell clone activated by a conformational determinant of the I-Ek molecule.

2. Cytolytic T cells activated by H-2-controlled E molecules cross-react with A molecules.

3. Human Ia molecules carrying DC1 or BR4X7 determinants are not homologous to murine I-E molecules.