Literature DB >> 6177248

Use of monoclonal antibodies in detection of melanoma-associated antigens in intact human tumors.

J J Thompson, M F Herlyn, D E Elder, W H Clark, Z Steplewski, H Koprowski.   

Abstract

The use of antimelanoma monoclonal antibodies on tissue sections using a two-step indirect immunoperoxidase technique is reported. Antibodies 691-13-17 and 691-I5-Nu4B reacted with dysplastic nevus cells and all melanomas tested, but not with normal skin melanocytes, intradermal nevi, or lentigines. Antibody 691-13-17, directed against DR antigen, reacted also with Langerhan's cells, macrophages, and a subpopulation of lymphocytes. Antibody 691-I5-Nu4B reacted only with melanomas. The technique allows analysis of the expression of antigens by tumor cells in situ.

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Year:  1982        PMID： 6177248      PMCID： PMC1916245     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  9 in total

1.  Preparation of a semipermanent mounting medium for fluorescent antibody studies.

Authors:  J RODRIGUEZ; F DEINHARDT
Journal:  Virology       Date:  1960-10       Impact factor: 3.616

2.  The role of cathepsin D in the pathogenesis of tuberculosis. A histochemical study employing unlabeled antibodies and the peroxidase-antiperoxidase complex.

Authors:  O Rojas-Espinosa; A M Dannenberg; L A Sternberger; T Tsuda
Journal:  Am J Pathol       Date:  1974-01       Impact factor: 4.307

3.  Structural characterization of the 'melanoma-specific' antigen detected by monoclonal antibody 691I5Nu-4-B.

Authors:  K F Mitchell; J P Fuhrer; Z Steplewski; H Koprowski
Journal:  Mol Immunol       Date:  1981-03       Impact factor: 4.407

4.  The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.

Authors:  R C Graham; M J Karnovsky
Journal:  J Histochem Cytochem       Date:  1966-04       Impact factor: 2.479

5.  Reactivity of monoclonal anti-melanoma antibodies with melanoma cells freshly isolated from primary and metastatic melanoma.

Authors:  Z Steplewski; M Herlyn; D Herlyn; W H Clark; H Koprowski
Journal:  Eur J Immunol       Date:  1979-01       Impact factor: 5.532

6.  Specific immunoreactivity of hybridoma-secreted monoclonal anti-melanoma antibodies to cultured cells and freshly derived human cells.

Authors:  M Herlyn; W H Clark; M J Mastrangelo; D P Guerry; D E Elder; D LaRossa; R Hamilton; E Bondi; R Tuthill; Z Steplewski; H Koprowski
Journal:  Cancer Res       Date:  1980-10       Impact factor: 12.701

7.  Study of antibodies against human melanoma produced by somatic cell hybrids.

Authors:  H Koprowski; Z Steplewski; D Herlyn; M Herlyn
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

8.  Dysplastic nevus syndrome: a phenotypic association of sporadic cutaneous melanoma.

Authors:  D E Elder; L I Goldman; S C Goldman; M H Greene; W H Clark
Journal:  Cancer       Date:  1980-10-15       Impact factor: 6.860

9.  Biochemical characterization of human melanoma cell surfaces: dissection with monoclonal antibodies.

Authors:  K F Mitchell; J P Fuhrer; Z Steplewski; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205
  9 in total
  7 in total

1.  Binding specificity of two monoclonal antiglioma antibodies: immunocytochemical studies using a new tissue embedding technique.

Authors:  S Krajewski; G Schwendemann; M Weizsäcker; W Wechsler; N de Tribolet
Journal:  Acta Neuropathol       Date:  1986       Impact factor: 17.088

2.  The value of immunohistochemistry in increasing diagnostic precision of undifferentiated tumours by the surgical pathologist.

Authors:  R Baumal; H J Kahn; D Bailey; M J Phillips; W Hanna
Journal:  Histochem J       Date:  1984-10

3.  Patterns of constitutive and IFN-gamma inducible expression of HLA class II molecules in human melanoma cell lines.

Authors:  T Rodríguez; R Méndez; A Del Campo; N Aptsiauri; J Martín; G Orozco; G Pawelec; D Schadendorf; F Ruiz-Cabello; F Garrido
Journal:  Immunogenetics       Date:  2006-12-20       Impact factor: 2.846

4.  Heterogeneity of primary and metastatic human malignant melanoma as detected with monoclonal antibodies in cryostat sections of biopsies.

Authors:  L Suter; E B Bröcker; J Brüggen; D J Ruiter; C Sorg
Journal:  Cancer Immunol Immunother       Date:  1983       Impact factor: 6.968

5.  Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes.

Authors:  A M Gown; A M Vogel; D Hoak; F Gough; M A McNutt
Journal:  Am J Pathol       Date:  1986-05       Impact factor: 4.307

Review 6.  Heterogeneous expression of cell-surface antigens in normal epithelia and their tumours, revealed by monoclonal antibodies.

Authors:  P A Edwards
Journal:  Br J Cancer       Date:  1985-02       Impact factor: 7.640

7.  Histopathological evaluation of cutaneous malignant melanoma: A retrospective study.

Authors:  Daniela-Elena Gheoca Mutu; Adelaida Avino; Andra-Elena Balcangiu-Stroescu; Mihai Mehedințu; Daniela Gabriela Bălan; Lăcrămioara Aurelia Brîndușe; Ana-Maria Popescu; Dorin Ionescu; Bogdan-Mihai Cristea; Luminiţa Florentina Tomescu; Cristian-Radu Jecan; Laura Răducu
Journal:  Exp Ther Med       Date:  2022-04-20       Impact factor: 2.447
  7 in total

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