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Literature DB >> 6177216

Effect of ketotifen and oxatomide on histamine secretion from mast cells.

Abstract

The anti-histaminic drugs ketotifen and oxatomide have a dual effect on rat peritoneal mast cells. At high concentrations they induce histamine release, whereas at low concentrations they inhibit secretion evoked by IgE-directed ligands. The latter effect is observed in the presence and absence of exogenous calcium. The significance of this result for the general mode of action of anti-anaphylactic drugs is discussed. Neither compound liberates histamine from isolated mesenteric cells from the rat or guinea pig, further emphasizing the functional heterogeneity of mast cells from different sources.

Entities: Chemical Species

Mesh：

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Year: 1982 PMID： 6177216 DOI： 10.1007/BF01965147

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

12 in total

1. The anti-anaphylactic and histamine-releasing properties of the antihistamines. Their effect on the mast cells.

Authors: I MOTA; W da SILVA
Journal: Br J Pharmacol Chemother Date: 1960-09

2. Inhibition and stimulation of histamine release by oxatomide.

Authors: C W Bierman; E S Assem; J L Mongar
Journal: Int J Immunopharmacol Date: 1979

3. Oxatomide, a new orally active drug which inhibits both the release and the effects of allergic mediators.

Authors: F Awouters; C J Niemegeers; J Van den Berk; J M Van Neuten; F M Lenaerts; M Borgers; K H Schellekens; A Broeckaert; J De Cree; P A Janssen
Journal: Experientia Date: 1977-12-15

4. Inhibition of histamine release from human lung in vitro by antihistamines and related drugs.

Authors: M K Church; C F Gradidge
Journal: Br J Pharmacol Date: 1980-08 Impact factor: 8.739

5. Isolation and some properties of mast cells from the mesentery of the rat and guinea pig.

Authors: F L Pearce; M Ennis
Journal: Agents Actions Date: 1980-04

6. Pharmacological models for characterizing new anti-asthmatics.

Authors: A Kumagai; H Tomioka
Journal: Triangle Date: 1978

7. Ketotifen: a histamine release inhibitor.

Authors: U Martin; D Roemer
Journal: Monogr Allergy Date: 1977

8. Inhibition of histamine secretion from mast cells.

Authors: M Ennis; A Truneh; J R White; F L Pearce
Journal: Nature Date: 1981-01-15 Impact factor: 49.962

9. Oxatomide: inhibition and stimulation of histamine release from human lung and leucocytes in vitro.

Authors: M K Church; C F Gradidge
Journal: Agents Actions Date: 1980-04

10. The effect of alkaline earth cations on the release of histamine from rat peritoneal mast cells treated with compound 48/80 and peptide 401.

Authors: G Atkinson; M Ennis; F L Pearce
Journal: Br J Pharmacol Date: 1979-03 Impact factor: 8.739

7 in total

Effect of ketotifen and oxatomide on histamine secretion from mast cells.

1. The anti-anaphylactic and histamine-releasing properties of the antihistamines. Their effect on the mast cells.

2. Inhibition and stimulation of histamine release by oxatomide.

3. Oxatomide, a new orally active drug which inhibits both the release and the effects of allergic mediators.

4. Inhibition of histamine release from human lung in vitro by antihistamines and related drugs.

5. Isolation and some properties of mast cells from the mesentery of the rat and guinea pig.

6. Pharmacological models for characterizing new anti-asthmatics.

7. Ketotifen: a histamine release inhibitor.

8. Inhibition of histamine secretion from mast cells.

9. Oxatomide: inhibition and stimulation of histamine release from human lung and leucocytes in vitro.

10. The effect of alkaline earth cations on the release of histamine from rat peritoneal mast cells treated with compound 48/80 and peptide 401.

1. Anesthetic management of an infant with a solitary mastocytoma.

2. Effects of antihistamines on isolated rat peritoneal mast cells and on model membrane systems.

Review 3. Histamine2 (H2)-receptor antagonists in the treatment of urticaria.

Review 4. Drug treatment of allergic conjunctivitis. A review of the evidence.

5. Non-specific effects of calcium entry antagonists in mast cells.

Review 6. Effector cell heterogeneity in immediate hypersensitivity reactions.

Review 7. Oxatomide. A review of its pharmacodynamic properties and therapeutic efficacy.