Literature DB >> 6175650

The control of globin and other eukaryotic genes.

O Smithies.   

Abstract

The hypothesis is advanced that eukaryotes control different parts of their genomes by the selective use of origins of replication. Replication of a gene from an origin upstream of the gene is postulated to open it for transcription under appropriate circumstances; replication of a gene from an origin downstream of the gene closes it. The applicability of this hypothesis to the control of the human beta-globin cluster of genes is considered.

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Year:  1982        PMID： 6175650     DOI： 10.1002/jcp.1041130421

Source DB:  PubMed          Journal:  J Cell Physiol Suppl        ISSN： 0737-1462


  22 in total

Review 1.  Relationship of eukaryotic DNA replication to committed gene expression: general theory for gene control.

Authors:  L P Villarreal
Journal:  Microbiol Rev       Date:  1991-09

2.  Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon.

Authors:  E H Brown; M A Iqbal; S Stuart; K S Hatton; J Valinsky; C L Schildkraut
Journal:  Mol Cell Biol       Date:  1987-01       Impact factor: 4.272

3.  Sequence organization and developmentally regulated transcription of a family of repetitive DNA sequences of Xenopus laevis.

Authors:  C D Riggs; J H Taylor
Journal:  Nucleic Acids Res       Date:  1987-11-25       Impact factor: 16.971

4.  Alpha-amanitin insensitive transcription of the human epsilon-globin gene.

Authors:  G Kollias; C E Sekeris; F G Grosveld
Journal:  Nucleic Acids Res       Date:  1985-11-25       Impact factor: 16.971

5.  Replication timing of 10 developmentally regulated genes in Physarum polycephalum.

Authors:  G Pierron; M Benard; E Puvion; R Flanagan; H W Sauer; D Pallotta
Journal:  Nucleic Acids Res       Date:  1989-01-25       Impact factor: 16.971

6.  Opposite replication polarity of the germ line c-myc gene in HeLa cells compared with that of two Burkitt lymphoma cell lines.

Authors:  M Leffak; C D James
Journal:  Mol Cell Biol       Date:  1989-02       Impact factor: 4.272

7.  Asynchronous DNA replication within the human beta-globin gene locus.

Authors:  E Epner; W C Forrester; M Groudine
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

8.  Polarity of DNA replication through the avian alpha-globin locus.

Authors:  C D James; M Leffak
Journal:  Mol Cell Biol       Date:  1986-04       Impact factor: 4.272

9.  Opposite replication polarities of transcribed and nontranscribed histone H5 genes.

Authors:  J P Trempe; Y I Lindstrom; M Leffak
Journal:  Mol Cell Biol       Date:  1988-04       Impact factor: 4.272

10.  Identification and characterization of a gene that is coamplified with dihydrofolate reductase in a methotrexate-resistant CHO cell line.

Authors:  P K Foreman; J L Hamlin
Journal:  Mol Cell Biol       Date:  1989-03       Impact factor: 4.272
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