Literature DB >> 6175209

Human leukocyte interferon-mediated granulopoietic differentiation arrest and its abrogation by lithium carbonate.

D S Verma, G Spitzer, J U Gutterman, M Beran, A R Zander, K B McCredie.   

Abstract

Interferon has been shown to inhibit erythropoietic and granulopoietic differentiation. Since lithium carbonate (Li) elevates granulocyte levels in a variety of neutropenic disorders, we investigated the effect of Li on human leukocyte interferon (HLIF)-mediated inhibition of granulopoietic differentiation. Using an agar culture technique for cloning granulocyte-macrophage progenitor cells (GM-CFC), we demonstrated that Li blocks HLIF-induced granulopoietic differentiation arrest in a dose-dependent manner. Results of removal of T lymphocytes from marrow cells suggest that this Li effect is not mediated through marrow T lymphocytes.

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Year:  1982        PMID： 6175209     DOI： 10.1002/ajh.2830120106

Source DB:  PubMed          Journal:  Am J Hematol        ISSN： 0361-8609            Impact factor:   10.047


  4 in total

Review 1.  Biological response modifiers and differentiation inducers. Current status in cancer research.

Authors:  P Reizenstein; G Mathé
Journal:  Drugs       Date:  1983-09       Impact factor: 9.546

2.  Effects of human alpha-interferon on granulocyte-macrophage progenitor cells (CFU-GM) in vitro.

Authors:  J S Schwamborn; R M Nickels; B D Katthagen; H W Pees; P G Scheurlen
Journal:  Blut       Date:  1988-03

3.  A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs.

Authors:  Michael F Denny; Srilakshmi Yalavarthi; Wenpu Zhao; Seth G Thacker; Marc Anderson; Ashley R Sandy; W Joseph McCune; Mariana J Kaplan
Journal:  J Immunol       Date:  2010-02-17       Impact factor: 5.422

4.  Lithium ion inhibits nerve growth factor-induced neurite outgrowth and phosphorylation of nerve growth factor-modulated microtubule-associated proteins.

Authors:  D E Burstein; P J Seeley; L A Greene
Journal:  J Cell Biol       Date:  1985-09       Impact factor: 10.539
  4 in total

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