Literature DB >> 3355900

Effects of human alpha-interferon on granulocyte-macrophage progenitor cells (CFU-GM) in vitro.

J S Schwamborn1, R M Nickels, B D Katthagen, H W Pees, P G Scheurlen.   

Abstract

Two preparations of human interferon (IFN)-alpha were assessed for their influence on granulocyte-macrophage progenitor cells (CFU-GM) in vitro. Both highly purified human IFN-alpha Ly and recombinant IFN-alpha 2a suppressed CFU-GM colony formation in a dose-dependent manner using low-density bone-marrow target cells. Suppression of CFU-GM colony formation was accompanied by an increase in clusters. However, depletion of monocytes, T lymphocytes and B lymphocytes from low-density bone-marrow cells resulted in insensitivity of progenitor cells to IFN-alpha. These results demonstrate that the effects of human IFN-alpha on myeloid progenitor cells (CFU-GM) are mediated by accessory cells within the bone marrow.

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Year:  1988        PMID： 3355900     DOI： 10.1007/bf00320013

Source DB:  PubMed          Journal:  Blut        ISSN： 0006-5242


  20 in total

1.  Cytotoxic effects of interferon in vitro on granulocytic progenitor cells.

Authors:  P L Greenberg; S A Mosny
Journal:  Cancer Res       Date:  1977-06       Impact factor: 12.701

2.  Suppression of normal human erythropoiesis by gamma interferon in vitro. Role of monocytes and T lymphocytes.

Authors:  S W Mamus; S Beck-Schroeder; E D Zanjani
Journal:  J Clin Invest       Date:  1985-05       Impact factor: 14.808

3.  Comparative analysis of the influences of human gamma, alpha and beta interferons on human multipotential (CFU-GEMM), erythroid (BFU-E) and granulocyte-macrophage (CFU-GM) progenitor cells.

Authors:  H E Broxmeyer; L Lu; E Platzer; C Feit; L Juliano; B Y Rubin
Journal:  J Immunol       Date:  1983-09       Impact factor: 5.422

4.  In vitro effect of interferon-alpha on human granulocyte/macrophage progenitor cells and human clonogenic tumor cells.

Authors:  E E Holdener; P Schnell; P Spieler; H Senn
Journal:  Recent Results Cancer Res       Date:  1984

5.  Detection of human histocompatibility (HLA) antigens with an indirect rosette microassay.

Authors:  F Indiveri; B S Wilson; M A Pellegrino; S Ferrone
Journal:  J Immunol Methods       Date:  1979       Impact factor: 2.303

6.  Isolation of myeloid progenitor cells from peripheral blood of chronic myelogenous leukemia patients.

Authors:  J D Griffin; R P Beveridge; S F Schlossman
Journal:  Blood       Date:  1982-07       Impact factor: 22.113

7.  Alpha-interferon: differential suppression of colony growth from human erythroid, myeloid, and megakaryocytic hematopoietic progenitor cells.

Authors:  E M Mazur; W J Richtsmeier; K South
Journal:  J Interferon Res       Date:  1986-06

8.  Human leukocyte interferon-mediated granulopoietic differentiation arrest and its abrogation by lithium carbonate.

Authors:  D S Verma; G Spitzer; J U Gutterman; M Beran; A R Zander; K B McCredie
Journal:  Am J Hematol       Date:  1982-02       Impact factor: 10.047

9.  The fractionation, characterization, and subcellular localization of colony-stimulating activities released by the human monocyte-like cell line, GCT.

Authors:  J F DiPersio; J K Brennan; M A Lichtman; C N Abboud; F H Kirkpatrick
Journal:  Blood       Date:  1980-10       Impact factor: 22.113

10.  Influence of interferon preparations on the proliferative capacity of human and mouse bone marrow cells in vitro.

Authors:  E van 't Hull; H Schellekens; B Löwenberg; M J de Vries
Journal:  Cancer Res       Date:  1978-04       Impact factor: 12.701
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