Literature DB >> 6174624

Interleukin 2 regulates immune interferon (IFN gamma) production by normal and suppressor cell cultures.

B A Torres, W L Farrar, H M Johnson.   

Abstract

A Lyt-2+ lymphocyte is responsible for immune interferon (IFN gamma) production in mitogen-stimulated mouse spleen cell cultures. A Lyt-1+ helper cell is required for the induction of IFN gamma. Interleukin 2 (IL 2) can specifically replace the Lyt 1 cell requirement. IL 2 will also abrogate suppressor cell inhibition of IFN gamma production. IFN gamma production appears to be regulated by a dynamic interaction between helper cells (source of IL 2), suppressor cells (absorption of IL 2?) and IFN gammna-producer cells.

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Year:  1982        PMID： 6174624

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  20 in total

1.  Involvement of gamma interferon in antibody enhancement by adjuvants.

Authors:  M J Odean; C M Frane; M Van derVieren; M A Tomai; A G Johnson
Journal:  Infect Immun       Date:  1990-02       Impact factor: 3.441

2.  Decrease in interferon-gamma production by peripheral blood mononuclear cells in patients with uterine cervical cancer.

Authors:  H Mori; T Hanabayashi; Y Yamada; T Tamaya
Journal:  J Clin Immunol       Date:  1990-01       Impact factor: 8.317

3.  Gamma-interferon production by human low-density lymphocytes induced by T-cell mitogens.

Authors:  A D Croll; M F Wilkinson; A G Morris
Journal:  Immunology       Date:  1986-08       Impact factor: 7.397

Review 4.  Lymphocyte proliferation, lymphokine production, and lymphocyte receptors in ageing and various clinical conditions.

Authors:  A L de Weck; F Kristensen; F Joncourt; F Bettens; C Walker; Y Wang
Journal:  Springer Semin Immunopathol       Date:  1984

5.  Gamma-interferon induction in human lymphoblasts compared with fresh mononuclear leucocytes: earlier synthesis, rapid shut-off and enhancement of yields by metabolic inhibitors.

Authors:  M F Wilkinson; A G Morris
Journal:  Immunology       Date:  1984-05       Impact factor: 7.397

6.  Studies on macrophage-activating factor (MAF) in antitumor immune responses. II. Molecular characterization of MAF produced by the tumor-immune Lyt-1+2- T cell subset.

Authors:  H Nakajima; Y Izumi; S Sugihara; Y Satoh; S Isumi; T Gotoh; H Fujiwara; T Hamaoka
Journal:  Cancer Immunol Immunother       Date:  1987       Impact factor: 6.968

7.  Decreased expression of human class II antigens on monocytes from patients with acquired immune deficiency syndrome. Increased expression with interferon-gamma.

Authors:  W Heagy; V E Kelley; T B Strom; K Mayer; H M Shapiro; R Mandel; R Finberg
Journal:  J Clin Invest       Date:  1984-12       Impact factor: 14.808

8.  Specific adoptive immunotherapy of malignant glioma with long-term cytotoxic T lymphocyte line expanded in T-cell growth factor. Experimental study and future prospects.

Authors:  T Yamasaki; H Handa; J Yamashita; Y Watanabe; Y Namba; M Hanaoka
Journal:  Neurosurg Rev       Date:  1984       Impact factor: 3.042

9.  Lung delayed-type hypersensitivity in stressed mice.

Authors:  F Blecha; D Topliff
Journal:  Can J Comp Med       Date:  1984-04

10.  Interleukin 2-dependent release of interleukin 3 activity by T4+ human T-cell clones.

Authors:  A A Ythier; M Abbud-Filho; J M Williams; R Loertscher; M W Schuster; A Nowill; J A Hansen; D Maltezos; T B Strom
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205
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