Literature DB >> 2413452

Interleukin 2-dependent release of interleukin 3 activity by T4+ human T-cell clones.

A A Ythier, M Abbud-Filho, J M Williams, R Loertscher, M W Schuster, A Nowill, J A Hansen, D Maltezos, T B Strom.   

Abstract

We have isolated and studied two alloreactive, T4+, human lymphocyte clones that release interleukin 2 (IL-2) and interleukin 3 (IL-3) bioactivities upon stimulation with IL-2, alloantigen, or Sepharose-conjugated antibodies directed against the T3 protein. Anti-IL-2 receptor monoclonal antibodies block IL-2-, alloantigen-, or anti-T3-stimulated IL-3 release. Hence, release of IL-3 activity in each circumstance is rigorously dependent upon activation of the IL-2 receptor. Even low, nonmitogenic concentrations of recombinant IL-2 stimulated IL-3 release.

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Year:  1985        PMID： 2413452      PMCID： PMC391301          DOI： 10.1073/pnas.82.20.7020

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  Interleukin 3 dependent retrovirus induced lymphomas: loss of the ability to terminally differentiate in response to differentiation factors.

Authors:  J N Ihle; H C Morse; J Keller; K L Holmes
Journal:  Curr Top Microbiol Immunol       Date:  1984       Impact factor: 4.291

2.  A 55,000 Mr surface antigen on activated human T lymphocytes defined by a monoclonal antibody.

Authors:  M E Hemler; B Malissen; N Rebai; A Liabeuf; C Mawas; F M Kourilsky; J L Strominger
Journal:  Hum Immunol       Date:  1983-10       Impact factor: 2.850

3.  Molecular cloning of cDNA for murine interleukin-3.

Authors:  M C Fung; A J Hapel; S Ymer; D R Cohen; R M Johnson; H D Campbell; I G Young
Journal:  Nature       Date:  1984 Jan 19-25       Impact factor: 49.962

4.  Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells.

Authors:  T Yokota; F Lee; D Rennick; C Hall; N Arai; T Mosmann; G Nabel; H Cantor; K Arai
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

5.  Production of lymphokines by circulating human T lymphocytes that express or lack receptors for interleukin 2.

Authors:  R Palacios
Journal:  J Immunol       Date:  1984-04       Impact factor: 5.422

6.  Different colony-stimulating factors are detected by the "interleukin-3"-dependent cell lines FDC-Pl and 32D cl-23.

Authors:  A J Hapel; H S Warren; D A Hume
Journal:  Blood       Date:  1984-10       Impact factor: 22.113

7.  Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

Authors:  S C Meuer; R E Hussey; D A Cantrell; J C Hodgdon; S F Schlossman; K A Smith; E L Reinherz
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

8.  Production of interleukin 2, interleukin 3, and interferon by mouse T lymphocyte clones of Lyt-2+ and -2- phenotype.

Authors:  P A Guerne; P F Piguet; P Vassalli
Journal:  J Immunol       Date:  1984-04       Impact factor: 5.422

9.  A cloned MCGF cDNA encodes a multilineage hematopoietic growth factor: multiple activities of interleukin 3.

Authors:  D M Rennick; F D Lee; T Yokota; K I Arai; H Cantor; G J Nabel
Journal:  J Immunol       Date:  1985-02       Impact factor: 5.422

10.  Direct demonstration of the identity of T cell growth factor binding protein and the Tac antigen.

Authors:  R J Robb; W C Greene
Journal:  J Exp Med       Date:  1983-10-01       Impact factor: 14.307
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  3 in total

1.  Presence of a very small population of Thy-1+, L3T4+ cells producing large amounts of IL-3 in young athymic nude mice.

Authors:  M Kimoto; S de Kossodo; V Kindler; M Detraz; P Vassalli; S Izui
Journal:  Immunology       Date:  1989-12       Impact factor: 7.397

2.  Triggering of thymocyte function by IL-2 as the only exogenous stimulus; analysis of two distinct modes of IL-2-induced thymocyte proliferation and IL-3 secretion in vitro.

Authors:  M Bellio; G A Dos Reis
Journal:  Immunology       Date:  1989-10       Impact factor: 7.397

3.  Differential regulation of colony-stimulating factors and interleukin 2 production by cyclosporin A.

Authors:  M Bickel; H Tsuda; P Amstad; V Evequoz; S E Mergenhagen; S M Wahl; D H Pluznik
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205
  3 in total

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