Literature DB >> 6171882

Sensory and motor functions of spinal cord substance P.

M F Piercey, L A Schroeder, K Folkers, J C Xu, J Horig.   

Abstract

Low doses of D-Pro2-D-Phe7-D-Trp9-substance P, as specific substance P antagonist, depressed the scratching and biting behaviors elicited by intrathecal injections of substance P, and cutaneous application of algesic substances. Higher antagonist doses caused hindlimb paralysis. This suggests that substance P is a neurotransmitter for primary nociceptor afferents and may also have an important function in motor control.

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Year:  1981        PMID： 6171882     DOI： 10.1126/science.6171882

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

1.  Origin and fine structure of substance P-containing nerve terminals in the facial nucleus of the rat: an immunohistochemical study.

Authors:  E Senba; M Tohyama
Journal:  Exp Brain Res       Date:  1985       Impact factor: 1.972

2.  The somato-visceral divergent projections of peripheral processes of substance P-containing spinal ganglionic neurons--tri-labeling study of combining fluorescein tracing with immunocytochemistry.

Authors:  Q Y Liu; C G Zhu
Journal:  J Tongji Med Univ       Date:  1989

3.  Immunohistochemical and behavioral analysis of spinal lesions induced by a substance P antagonist and protection by thyrotropin releasing hormone.

Authors:  J Freedman; T Hökfelt; C Post; E Brodin; E Sundström; G Jonsson; L Terenius; S Leander; J A Fischer; A Verhofstad
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

4.  Fluorescent double-labelling study of ascending and descending neurones in the feline lateral cervical nucleus.

Authors:  R Flink; B A Svensson
Journal:  Exp Brain Res       Date:  1986       Impact factor: 1.972

5.  Naloxone-reversible effect of spantide on the spinally mediated behavioural response induced by neurokinin-2 and -3 receptor agonists.

Authors:  T Sakurada; Y Manome; K Katsumata; H Uchiumi; K Tan-No; S Sakurada; K Kisara
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-07       Impact factor: 3.000

6.  Modification of lymphocyte traffic by vasoactive neurotransmitter substances.

Authors:  T C Moore
Journal:  Immunology       Date:  1984-07       Impact factor: 7.397

7.  Effects of percutaneous stimulation on motor unit firing behavior in man.

Authors:  Y Masakado; G Kamen; C J De Luca
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

8.  Capsaicin-induced reflex fall in rat blood pressure is mediated by afferent substance P-containing neurones via a reflex centre in the brain stem.

Authors:  J Donnerer; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-12       Impact factor: 3.000

9.  Capsaicin and nociception in the rat and mouse. Possible role of substance P.

Authors:  R Gamse
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-09       Impact factor: 3.000

10.  Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists.

Authors:  B F Cox; R L Schelper; F M Faraci; M J Brody
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972
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