Literature DB >> 6198593

Capsaicin-induced reflex fall in rat blood pressure is mediated by afferent substance P-containing neurones via a reflex centre in the brain stem.

J Donnerer, F Lembeck.   

Abstract

Injection of 0.03 micrograms capsaicin into one femoral artery elicited a fall in blood pressure in the rat. This effect was completely and reversibly abolished following intrathecal injection of 1 nmol of the specific substance P antagonist, [D-Pro2,D-Trp7,9] substance P. The capsaicin-evoked depressor reflex is therefore exclusively mediated by substance P-containing primary afferent fibres. Using spinal rats or decerebration experiments, the centre of the capsaicin-evoked reflex fall in blood pressure could be localized in the brain stem.

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Year:  1983        PMID： 6198593     DOI： 10.1007/bf00502626

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  21 in total

1.  Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation.

Authors:  F Lembeck; P Holzer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-12       Impact factor: 3.000

2.  A synthetic peptide as an antagonist of substance P.

Authors:  G Engberg; T H Svensson; S Rosell; K Folkders
Journal:  Nature       Date:  1981 Sep 17-23       Impact factor: 49.962

3.  Immunohistochemical studies on the effect of capsaicin on spinal and medullary peptide and monoamine neurons using antisera to substance P, gastrin/CCK, somatostatin, VIP, enkephalin, neurotensin and 5-hydroxytryptamine.

Authors:  G Jancsó; T Hökfelt; J M Lundberg; E Kiraly; N Halász; G Nilsson; L Terenius; J Rehfeld; H Steinbusch; A Verhofstad; R Elde; S Said; M Brown
Journal:  J Neurocytol       Date:  1981-12

4.  Differential effects of capsaicin on the content of somatostatin, substance P, and neurotensin in the nervous system of the rat.

Authors:  R Gamse; S E Leeman; P Holzer; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-09       Impact factor: 3.000

5.  A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain.

Authors:  J Szolcsányi
Journal:  J Physiol (Paris)       Date:  1977-09

6.  Pharmacological characterization of substance P-induced nociception in mice: modulation by opioid and noradrenergic agonists at the spinal level.

Authors:  J L Hylden; G L Wilcox
Journal:  J Pharmacol Exp Ther       Date:  1983-08       Impact factor: 4.030

7.  Decrease of substance P in primary afferent neurones and impairment of neurogenic plasma extravasation by capsaicin.

Authors:  R Gamse; P Holzer; F Lembeck
Journal:  Br J Pharmacol       Date:  1980-02       Impact factor: 8.739

8.  Phenyldiguanide and capsaicin stimulate functionally different populations of afferent C-fibers.

Authors:  G Skofitsch; A Saria; F Lembeck
Journal:  Neurosci Lett       Date:  1983-11-21       Impact factor: 3.046

9.  Blood pressure and splanchnic nerve activity are reduced by a vagally mediated opioid action.

Authors:  R N Willette; A J Krieger; H N Sapru
Journal:  J Cardiovasc Pharmacol       Date:  1982 Nov-Dec       Impact factor: 3.105

10.  Analysis of the effects of intravenously injected capsaicin in the rat.

Authors:  J Donnerer; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-07       Impact factor: 3.000
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  15 in total

1.  Effects of capsaicin on vascular smooth muscle.

Authors:  S P Duckles
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-05       Impact factor: 3.000

2.  Capsaicin-sensitive afferents activate a sympathetic intestinointestinal inhibitory reflex in dogs.

Authors:  M Mizutani; T Neya; S Nakayama
Journal:  J Physiol       Date:  1990-06       Impact factor: 5.182

3.  Capsaicin sensitive afferent neurons from peripheral glucose receptors mediate the insulin-induced increase in adrenaline secretion.

Authors:  R Amann; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-09       Impact factor: 3.000

4.  Primary sensory neurones and naloxone-precipitated morphine withdrawal.

Authors:  J Donnerer
Journal:  Br J Pharmacol       Date:  1989-04       Impact factor: 8.739

5.  Decreased vascular permeability response to substance P in airways of genetically hypertensive rats.

Authors:  Y S Bakhle; J D Brogan; C Bell
Journal:  Br J Pharmacol       Date:  1999-02       Impact factor: 8.739

6.  Reflex activation of the adrenal medulla during hypoglycemia and circulatory dysregulations is regulated by capsaicin-sensitive afferents.

Authors:  J Donnerer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-09       Impact factor: 3.000

7.  Capsaicin-sensitive afferents in the rat urinary bladder activate a spinal sympathetic cardiovascular reflex.

Authors:  S Giuliani; C A Maggi; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-10       Impact factor: 3.000

8.  CP-96,345, a non-peptide antagonist of substance P: II. Actions on substance P-induced hypotension and bronchoconstriction, and on depressor reflexes in mammals.

Authors:  T Griesbacher; J Donnerer; F J Legat; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-09       Impact factor: 3.000

9.  Effects of clonidine and yohimbine on a C-fibre-evoked blood pressure reflex in the rat.

Authors:  J Donnerer; Z Yan; F Lembeck
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

10.  Absorption and metabolism of capsaicinoids following intragastric administration in rats.

Authors:  J Donnerer; R Amann; R Schuligoi; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-09       Impact factor: 3.000
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