Literature DB >> 6171248

Regulation of actin polymerizaton in rat islets of Langerhans.

S L Howell, M Tyhurst.   

Abstract

A DNAase-inhibition assay was used to determine the proportions of globular (G-) and filamentous (F-) actin in islets of Langerhans after incubation in various conditions, or after subcellular fractionation. Stimulation of insulin secretion resulted in an ATP-dependent increase in the proportion of F-actin present; fractionation showed 80-90% of the actin to be present in the final supernatant.

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Year:  1980        PMID： 6171248      PMCID： PMC1162347          DOI： 10.1042/bj1920381

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  8 in total

1.  Association of actin and myosin with secretory granule membranes.

Authors:  K Burridge; J H Phillips
Journal:  Nature       Date:  1975-04-10       Impact factor: 49.962

2.  Interaction between insulin-storage granules and F-actin in vitro.

Authors:  S L Howell; M Tyhurst
Journal:  Biochem J       Date:  1979-02-15       Impact factor: 3.857

3.  Pancreatic beta-cell web: its possible role in insulin secretion.

Authors:  L Orci; K H Gabbay; W J Malaisse
Journal:  Science       Date:  1972-03-10       Impact factor: 47.728

4.  New hypothesis of insulin secretion.

Authors:  P E Lacy; S L Howell; D A Young; C J Fink
Journal:  Nature       Date:  1968-09-14       Impact factor: 49.962

5.  Effects of glucose concentration on incorporation of [3H]leucine into insulin using isolated mammalian islets of Langerhans.

Authors:  S L Howell; K W Taylor
Journal:  Biochim Biophys Acta       Date:  1966-12-28

6.  Selective assay of monomeric and filamentous actin in cell extracts, using inhibition of deoxyribonuclease I.

Authors:  I Blikstad; F Markey; L Carlsson; T Persson; U Lindberg
Journal:  Cell       Date:  1978-11       Impact factor: 41.582

7.  Muscle actin filaments bind pituitary secretory granules in vitro.

Authors:  R E Ostlund; J T Leung; D M Kipnis
Journal:  J Cell Biol       Date:  1977-04       Impact factor: 10.539

8.  Isolation and properties of secretory granules from rat islets of Langerhans. I. Isolation of a secretory granule fraction.

Authors:  S L Howell; C J Fink; P E Lacy
Journal:  J Cell Biol       Date:  1969-04       Impact factor: 10.539
  8 in total
  8 in total

1.  Activation of alpha-2-adrenoceptors results in an increase in F-actin formation in HIT-T15 pancreatic B-cells.

Authors:  H C Cable; A el-Mansoury; N G Morgan
Journal:  Biochem J       Date:  1995-04-01       Impact factor: 3.857

2.  Effect of disruption of actin filaments by Clostridium botulinum C2 toxin on insulin secretion in HIT-T15 cells and pancreatic islets.

Authors:  G Li; E Rungger-Brändle; I Just; J C Jonas; K Aktories; C B Wollheim
Journal:  Mol Biol Cell       Date:  1994-11       Impact factor: 4.138

Review 3.  Microtubules, microfilaments and insulin-secretion.

Authors:  S L Howell; M Tyhurst
Journal:  Diabetologia       Date:  1982-05       Impact factor: 10.122

Review 4.  The mechanism of insulin secretion.

Authors:  S L Howell
Journal:  Diabetologia       Date:  1984-05       Impact factor: 10.122

5.  Actomyosin interactions with insulin-storage granules in vitro.

Authors:  S L Howell; M Tyhurst
Journal:  Biochem J       Date:  1982-07-15       Impact factor: 3.857

6.  Glucose-induced ERM protein activation and translocation regulates insulin secretion.

Authors:  James P Lopez; Jerrold R Turner; Louis H Philipson
Journal:  Am J Physiol Endocrinol Metab       Date:  2010-08-24       Impact factor: 4.310

7.  Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin.

Authors:  S Asahara; Y Shibutani; K Teruyama; H Y Inoue; Y Kawada; H Etoh; T Matsuda; M Kimura-Koyanagi; N Hashimoto; M Sakahara; W Fujimoto; H Takahashi; S Ueda; T Hosooka; T Satoh; H Inoue; M Matsumoto; A Aiba; M Kasuga; Y Kido
Journal:  Diabetologia       Date:  2013-02-15       Impact factor: 10.122

Review 8.  Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells.

Authors:  Michael A Kalwat; Debbie C Thurmond
Journal:  Exp Mol Med       Date:  2013-08-23       Impact factor: 8.718
  8 in total

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