Literature DB >> 6169587

Light microscopic localization of hepatitis B virus antigens in the human pancreas. Possibility of multiplication of hepatitis B virus in the human pancreas.

T Shimoda, T Shikata, T Karasawa, S Tsukagoshi, M Yoshimura, I Sakurai.   

Abstract

Hepatitis B virus has been considered to be strictly organotropic and to infect and multiply only the hepatocytes of humans and chimpanzees. The localization of hepatitis B surface antigen in extrahepatic tissues has been regarded as due to deposition or phagocytosis of hepatitis B surface antigen circulating in the blood. In the present study, however, we demonstrated hepatitis B virus antigens in the pancreases of autopsied subjects with hepatitis B surface antigenemia by Shikata's orcein stain, and immunoperoxidase, immunofluorescent studies; hepatitis B surface antigen and hepatitis B virus core antigen were localized within the cytoplasm of pancreatic acinar cells in 18 and 6 cases, respectively, out of 30 cases studied. In contrast, 25 autopsy cases with no hepatitis B surface antigenemia failed to stain hepatitis B surface antigen or hepatitis B core antigen in the pancreas and liver. Therefore, it may be reasonable to assume that hepatitis B virus can infect and replicate in the human pancreatic acinar cells; however no convincing hepatitis B virus-associated ultrastructures were detected in the present study. Although there were some cases demonstrating chronic inflammatory reaction or fatty necrosis, or both, in the pancreas with hepatitis B virus antigens, the causal relationship between these pathologic changes and hepatitis B virus infection awaits further clarification.

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Year:  1981        PMID: 6169587

Source DB:  PubMed          Journal:  Gastroenterology        ISSN: 0016-5085            Impact factor:   22.682


  28 in total

1.  Lamivudine treatment for recurrent pancreatitis associated with reactivation of chronic B hepatitis.

Authors:  Chien-Hung Chen; Chi-Sin Changchien; Sheng-Nan Lu; Jing-Houng Wang; Chao-Hung Hung; Chuan-Mo Lee
Journal:  Dig Dis Sci       Date:  2002-03       Impact factor: 3.199

Review 2.  Hepatitis B virus biology.

Authors:  C Seeger; W S Mason
Journal:  Microbiol Mol Biol Rev       Date:  2000-03       Impact factor: 11.056

3.  Pancreatic involvement in chronic viral hepatitis.

Authors:  Yoshiki Katakura; Hiroshi Yotsuyanagi; Kiyoe Hashizume; Chiaki Okuse; Noriaki Okuse; Kohji Nishikawa; Michihiro Suzuki; Shiro Iino; Fumio Itoh
Journal:  World J Gastroenterol       Date:  2005-06-21       Impact factor: 5.742

4.  Acute pancreatitis complicating spontaneous acute exacerbation of chronic hepatitis B virus infection: case report and review of the literature.

Authors:  Kyo-Sang Yoo; Kyung-Hun Lee; Kyung Rim Huh; Won Sub Choi; Gang Jeon; Jun-Wook Ha; Kyoung Oh Kim; Cheol Hee Park; Taeho Hahn; Sang Hoon Park; Jong Hyeok Kim; Choong Kee Park
Journal:  Gut Liver       Date:  2009-03-31       Impact factor: 4.519

5.  Major polypeptide of duck hepatitis B surface antigen particles.

Authors:  P L Marion; S S Knight; M A Feitelson; L S Oshiro; W S Robinson
Journal:  J Virol       Date:  1983-11       Impact factor: 5.103

Review 6.  Idiopathic acute pancreatitis: a review on etiology and diagnostic work-up.

Authors:  Giovanna Del Vecchio Blanco; Cristina Gesuale; Marzia Varanese; Giovanni Monteleone; Omero Alessandro Paoluzi
Journal:  Clin J Gastroenterol       Date:  2019-04-30

7.  Viral nucleic acid synthesis and antigen accumulation in pancreas and kidney of Pekin ducks infected with duck hepatitis B virus.

Authors:  M S Halpern; J M England; D T Deery; D J Petcu; W S Mason; K L Molnar-Kimber
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205

8.  Detection of hepatitis B virus DNA in hepatocytes, bile duct epithelium, and vascular elements by in situ hybridization.

Authors:  H E Blum; L Stowring; A Figus; C K Montgomery; A T Haase; G N Vyas
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

9.  Association between hepatitis B virus and pancreatic cancer.

Authors:  Manal M Hassan; Donghui Li; Adel S El-Deeb; Robert A Wolff; Melissa L Bondy; Marta Davila; James L Abbruzzese
Journal:  J Clin Oncol       Date:  2008-10-01       Impact factor: 44.544

Review 10.  Hepatitis B virus infection and primary hepatocellular carcinoma.

Authors:  M Feitelson
Journal:  Clin Microbiol Rev       Date:  1992-07       Impact factor: 26.132

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