Literature DB >> 6579553

Detection of hepatitis B virus DNA in hepatocytes, bile duct epithelium, and vascular elements by in situ hybridization.

H E Blum, L Stowring, A Figus, C K Montgomery, A T Haase, G N Vyas.   

Abstract

A radiolabeled probe specific for hepatitis B virus (HBV) nucleotide sequences was hybridized in situ to liver tissue from three patients with chronic hepatitis B. The HBV genome was detected not only in infected hepatocytes but also in bile duct epithelial cells, endothelial cells, and smooth muscle cells. These findings extend the known host cell range for HBV, suggest new mechanisms of viral dissemination, and illustrate the usefulness of in situ hybridization in the study of pathogenesis of HBV infection.

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Year:  1983        PMID： 6579553      PMCID： PMC391235          DOI： 10.1073/pnas.80.21.6685

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  35 in total

1.  Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

Authors:  P S Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

2.  Preparative and analytical purification of DNA from agarose.

Authors:  B Vogelstein; D Gillespie
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

3.  Biology of hepatitis B virus.

Authors:  P Tiollais; P Charnay; G N Vyas
Journal:  Science       Date:  1981-07-24       Impact factor: 47.728

4.  Acute and chronic hepatitis revisited. Review by an international group.

Authors: 
Journal:  Lancet       Date:  1977-10-29       Impact factor: 79.321

5.  Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma.

Authors:  C Brechot; C Pourcel; A Louise; B Rain; P Tiollais
Journal:  Nature       Date:  1980-07-31       Impact factor: 49.962

6.  State of hepatitis B viral DNA in a human hepatoma cell line.

Authors:  P L Marion; F H Salazar; J J Alexander; W S Robinson
Journal:  J Virol       Date:  1980-02       Impact factor: 5.103

7.  Integration of hepatitis B virus sequences and their expression in a human hepatoma cell.

Authors:  J C Edman; P Gray; P Valenzuela; L B Rall; W J Rutter
Journal:  Nature       Date:  1980-07-31       Impact factor: 49.962

8.  State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases.

Authors:  C Bréchot; M Hadchouel; J Scotto; M Fonck; F Potet; G N Vyas; P Tiollais
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

9.  Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. Studies in percutaneous liver biopsies and post-mortem tissue specimens.

Authors:  D A Shafritz; D Shouval; H I Sherman; S J Hadziyannis; M C Kew
Journal:  N Engl J Med       Date:  1981-10-29       Impact factor: 91.245

10.  Integration pattern of hepatitis B virus DNA sequences in human hepatoma cell lines.

Authors:  E M Twist; H F Clark; D P Aden; B B Knowles; S A Plotkin
Journal:  J Virol       Date:  1981-01       Impact factor: 5.103
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  34 in total

Review 1.  Molecular techniques in the diagnosis of human infectious diseases.

Authors:  U Desselberger; K Collingham
Journal:  Genitourin Med       Date:  1990-10

Review 2.  In situ hybridisation in perspective.

Authors:  A Warford; I Lauder
Journal:  J Clin Pathol       Date:  1991-03       Impact factor: 3.411

3.  Pharmacokinetics of the antiviral agent beta-L-3'-fluoro-2',3'-didehydro-2',3'-dideoxycytidine in rhesus monkeys.

Authors:  Ghazia Asif; Selwyn J Hurwitz; Giuseppe Gumina; Chung K Chu; Harold M McClure; Raymond F Schinazi
Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

4.  In vitro hepatitis B virus infection of human bone marrow cells.

Authors:  J B Zeldis; H Mugishima; H N Steinberg; E Nir; R P Gale
Journal:  J Clin Invest       Date:  1986-08       Impact factor: 14.808

Review 5.  Hepatitis B virus. New and evolving issues.

Authors:  B Yoffe; C A Noonan
Journal:  Dig Dis Sci       Date:  1992-01       Impact factor: 3.199

Review 6.  Human herpesviruses: a consideration of the latent state.

Authors:  J G Stevens
Journal:  Microbiol Rev       Date:  1989-09

7.  Scrapie prion proteins are synthesized in neurons.

Authors:  H A Kretzschmar; S B Prusiner; L E Stowring; S J DeArmond
Journal:  Am J Pathol       Date:  1986-01       Impact factor: 4.307

8.  Hepatitis B virus differentially suppresses myelopoiesis and displays tropism for immature hematopoietic cells.

Authors:  G K Sing; S Prior; A Fernan; G Cooksley
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103

9.  Risk factors for intrahepatic cholangiocarcinoma: a case-control study in China.

Authors:  Yan-Ming Zhou; Zheng-Feng Yin; Jia-Mei Yang; Bin Li; Wen-Yu Shao; Feng Xu; Yu-Lan Wang; Dian-Qi Li
Journal:  World J Gastroenterol       Date:  2008-01-28       Impact factor: 5.742

Review 10.  Hepatitis B virus infection. Current concepts of chronicity and immunity.

Authors:  G N Vyas; H E Blum
Journal:  West J Med       Date:  1984-05
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