Literature DB >> 6169576

Acute renal hypertrophy in experimental diabetes: lack of effect of short-term growth hormone administration.

K Seyer-Hansen, H J Gundersen, R Osterby.   

Abstract

Normal and diabetic rats were given daily injections of human growth hormone for four days (5 mg per rat per day). Injected rats showed no differences from uninjected controls with respect to kidney weight or renal content of protein, RNA or DNA. Kidney weight increased by 7% after two days of diabetes and by 20% after four days, but growth hormone caused no augmentation of the hypertrophy. It is concluded that growth hormone plays no role in the initiation of diabetic renal hypertrophy.

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Year:  1981        PMID： 6169576     DOI： 10.1007/BF00252684

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  11 in total

1.  A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Hormonal interactions among GH, ACTH, cortisol and dexamethasone upon size of kidney, liver, and adrenal.

Authors:  R W Bates; M M Garrison
Journal:  Proc Soc Exp Biol Med       Date:  1974-07

4.  Increased kidney size and glomerular filtration rate in early juvenile diabetes.

Authors:  C E Mogensen; M J Andersen
Journal:  Diabetes       Date:  1973-09       Impact factor: 9.461

5.  Growth hormone secretion and kidney function during normalization of the metabolic state in newly diagnosed juvenile diabetes.

Authors:  A P Hansen; C E Mogensen
Journal:  Horm Metab Res       Date:  1972-01       Impact factor: 2.936

6.  Experimental hypersomatotropism. II. Metabolic effects in rats bearing the MtT-W15 tumor.

Authors:  H K Akerblom; J M Martin; G L Garay; M Moscarello
Journal:  Horm Metab Res       Date:  1972-01       Impact factor: 2.936

7.  Serum growth hormone patterns in juvenile diabetes.

Authors:  A P Hansen
Journal:  Dan Med Bull       Date:  1972-04

Review 8.  The determination of nucleic acids.

Authors:  H N Munro
Journal:  Methods Biochem Anal       Date:  1966

9.  Growth hormone enhances basement membrane thickening in experimental diabetes. A preliminary report.

Authors:  R Osterby; K Seyer-Hansen; H J Gundersen; K Lundbaek
Journal:  Diabetologia       Date:  1978-12       Impact factor: 10.122

10.  Renal hypertrophy in streptozotocin-diabetic rats.

Authors:  K Seyer-Hansen
Journal:  Clin Sci Mol Med       Date:  1976-12
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  3 in total

1.  The impact of renal growth, regression and regrowth in experimental diabetes mellitus on number and size of proximal and distal tubular cells in the rat kidney.

Authors:  J R Nyengaard; A Flyvbjerg; R Rasch
Journal:  Diabetologia       Date:  1993-11       Impact factor: 10.122

2.  Somatostatin analogue administration prevents increase in kidney somatomedin C and initial renal growth in diabetic and uninephrectomized rats.

Authors:  A Flyvbjerg; J Frystyk; O Thorlacius-Ussing; H Orskov
Journal:  Diabetologia       Date:  1989-04       Impact factor: 10.122

Review 3.  Renal effects of growth hormone. I. Renal function and kidney growth.

Authors:  G D Ogle; A R Rosenberg; G Kainer
Journal:  Pediatr Nephrol       Date:  1992-07       Impact factor: 3.714
  3 in total

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