Literature DB >> 6168489

Further support for the postsynaptic action of substance P and its blockade with baclofen in neurons of the guinea-pig hypothalamus in vitro.

N Ogata, H Abe.   

Abstract

Effects of substance P on neurons of the guinea-pig hypothalamus in vitro and antagonism between substance P and baclofen were investigated. Substance P increased the firing rate of neurons in the medium containing 0 mM Ca2+ and 12 mM Mg2+. The excitatory action of substance P was antagonized by a low dose of baclofen whereas that of acetylcholine was not antagonized even by much higher doses of baclofen.

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Year:  1981        PMID： 6168489     DOI： 10.1007/BF01967965

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  Antagonism between Lioresal and substance P in rat spinal cord.

Authors:  K Saito; S Konishi; M Otsuka
Journal:  Brain Res       Date:  1975-10-24       Impact factor: 3.252

2.  Post mortem changes and regional distribution of substance P in the rat and mouse nervous system.

Authors:  I Kanazawa; T Jessell
Journal:  Brain Res       Date:  1976-11-26       Impact factor: 3.252

3.  Actions of the p-chlorophenyl derivative of GABA, Lioresal, on nociceptive and non-nociceptive units in the spinal cord of the cat.

Authors:  J L Henry; Y Ben-Ari
Journal:  Brain Res       Date:  1976-12-03       Impact factor: 3.252

4.  Substance P causes direct depolarisation of neurones of guinea pig interpeduncular nucleus in vitro.

Authors:  N Ogata
Journal:  Nature       Date:  1979-02-08       Impact factor: 49.962

5.  Specific binding of 3H-substance P to rat brain membranes.

Authors:  M R Hanley; B E Sandberg; C M Lee; L L Iversen; D E Brundish; R Wade
Journal:  Nature       Date:  1980-08-21       Impact factor: 49.962

6.  Electrophysiology of mammalian hypothalamic and interpeduncular neurons in vitro.

Authors:  N Ogata
Journal:  Experientia       Date:  1979-09-15

7.  Is Lioresal (Baclofen) an antagonist of substance P?

Authors:  K J Fotherby; N J Morrish; R W Ryall
Journal:  Brain Res       Date:  1976-08-20       Impact factor: 3.252

8.  Is beta-(4-chlorophenyl)-GABA a specific antagonist of substance P on cerebral cortical neurons?

Authors:  J W Phillis
Journal:  Experientia       Date:  1976-05-15
  8 in total
  2 in total

1.  Properties of a 125I-substance P derivative binding to synaptosomes from various brain structures and the spinal cord of the rat.

Authors:  Y Torrens; J C Beaujouan; A Viger; J Glowinski
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-09       Impact factor: 3.000

2.  The effects of substance P on smooth muscle cells and on neuro-effector transmission in the guinea-pig ileum.

Authors:  K Fujisawa; Y Ito
Journal:  Br J Pharmacol       Date:  1982-06       Impact factor: 8.739
  2 in total

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