Literature DB >> 1278305

Is beta-(4-chlorophenyl)-GABA a specific antagonist of substance P on cerebral cortical neurons?

J W Phillis.   

Abstract

Beta-(4-chlorophenyl)-GABA (Baclofen, Lioresal) antagonized the excitant actions of acetylcholine and substance P to comparable extents. L-glutamate-induced excitation was affected to a lesser extent. These findings do not support the suggestion that beta-(4-chlorophenyl)-GABA is a specific substance P antagonist.

Entities:  

Mesh：

Substances：

Year:  1976        PMID： 1278305     DOI： 10.1007/BF01990181

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  Antagonism between Lioresal and substance P in rat spinal cord.

Authors:  K Saito; S Konishi; M Otsuka
Journal:  Brain Res       Date:  1975-10-24       Impact factor: 3.252

2.  Presynaptic action of beta(4-chlorophenyl)-gaba.

Authors:  F K Pierau; G K Matheson; R D Wurster
Journal:  Exp Neurol       Date:  1975-08       Impact factor: 5.330

3.  Excitation of cerebral cortical neurons by various polypeptides.

Authors:  J W Phillis; J J Limacher
Journal:  Exp Neurol       Date:  1974-05       Impact factor: 5.330

4.  Central effects of beta-(para-chlorophenyl)-gamma-aminobutyric acid.

Authors:  D R Curtis; C J Game; G A Johnston; R M McCulloch
Journal:  Brain Res       Date:  1974-04-26       Impact factor: 3.252

5.  Action of a GABA-derivative on postsynaptic potentials and membrane properties of cats' spinal motoneurones.

Authors:  F K Pierau; P Zimmermann
Journal:  Brain Res       Date:  1973-05-17       Impact factor: 3.252

6.  The effects of Lioresal on synaptic activity in the isolated spinal cord.

Authors:  R A Davidoff; E S Sears
Journal:  Neurology       Date:  1974-10       Impact factor: 9.910

7.  The action of beta-phenyl-GABA derivatives on neurones of the cat cerebral cortex.

Authors:  J Davies; J C Watkins
Journal:  Brain Res       Date:  1974-04-26       Impact factor: 3.252

8.  Substance P excitation of cerebral cortical Betz cells.

Authors:  J W Phillis; J J Limacher
Journal:  Brain Res       Date:  1974-03-29       Impact factor: 3.252
  8 in total
  3 in total

1.  Further support for the postsynaptic action of substance P and its blockade with baclofen in neurons of the guinea-pig hypothalamus in vitro.

Authors:  N Ogata; H Abe
Journal:  Experientia       Date:  1981-07-15

2.  Peripheral acting muscle relaxants alter the effects of baclofen on the electrocorticograms in the rat.

Authors:  I Yokoi; K Akiyama; H Kabuto; K Fukuyama; Y Nishijima; A Mori
Journal:  J Neural Transm Gen Sect       Date:  1992

3.  Selective depression of synaptic excitation in cat spinal neurones by baclofen: an iontophoretic study.

Authors:  J Davies
Journal:  Br J Pharmacol       Date:  1981-02       Impact factor: 8.739
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.