Literature DB >> 6168277

Enhanced cytotoxicity of antineoplastic agents following prolonged exposure to misonidazole.

L A Roizin-Towle, E J Hall.   

Abstract

Chinese hamster V79 cells cultured in vitro were used to investigated the cytotoxicity of various anti-cancer drugs subsequent to a prolonged treatment of the cells with Misonidazole (MISO). The sensitivity of the cells to Bleomycin (BLM), Melphalan or cis-Platinum (cis-DDP) was significantly increased by prior incubation with MISO under hypoxic conditions. When cysteamine, a radical scavenger, was present during the pretreatment with MISO, this enhancement of cytotoxicity was greatly reduced. These experiments, suggest that MISO by virtue of its selective toxicity towards hypoxic cells and its enhancement of cell killing by anti-neoplastic drugs, can play an important role in cancer chemotherapy.

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Year:  1981        PMID： 6168277      PMCID： PMC2010744          DOI： 10.1038/bjc.1981.171

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  18 in total

1.  Hypoxic sensitizers: radiobiological studies at the cellular level.

Authors:  E J Hall; L Roizin-Towle
Journal:  Radiology       Date:  1975-11       Impact factor: 11.105

2.  Radiosensitizers of hypoxic cells in solid tumors.

Authors:  J F Fowler; G E Adams; J Denekamp
Journal:  Cancer Treat Rev       Date:  1976-12       Impact factor: 12.111

3.  The response of a transplantable tumor to fractionated irradiation. 1. X rays and the hypoxic cell radiosensitizer Ro-07-0582.

Authors:  J Denekamp; S R Harris
Journal:  Radiat Res       Date:  1976-04       Impact factor: 2.841

4.  Selective radiosensitization of the hypoxic cells of mouse tumors with the nitroimidazoles metronidazole and Ro 7-0582.

Authors:  J M Brown
Journal:  Radiat Res       Date:  1975-12       Impact factor: 2.841

5.  Radiosensitizing and toxic effects on the 2-nitroimidazole Ro-07-0582 in hypoxic mammation cells.

Authors:  B A Moore; B Palcic; L D Skarsgard
Journal:  Radiat Res       Date:  1976-09       Impact factor: 2.841

6.  Electron-affinic sensitization. I. A structural basis for chemical radiosensitizers in bacteria.

Authors:  G E Adams; M S Cooke
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1969-07

7.  Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells.

Authors:  J K Mohindra; A M Rauth
Journal:  Cancer Res       Date:  1976-03       Impact factor: 12.701

8.  The application in radiation therapy of substances which modify cellular radiation response.

Authors:  J D Chapman; R C Urtasun
Journal:  Cancer       Date:  1977-07       Impact factor: 6.860

9.  Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro-07-0582, on mammalian cells in vitro.

Authors:  I J Stratford; G E Adams
Journal:  Br J Cancer       Date:  1977-03       Impact factor: 7.640

10.  Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.

Authors:  E J Hall; M Astor; C Geard; J Biaglow
Journal:  Br J Cancer       Date:  1977-06       Impact factor: 7.640
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  9 in total

1.  Cranial radiation and concomitant cisplatin and mitomycin-C plus resistance modulators for malignant gliomas.

Authors:  D J Stewart; S Dahrouge; O Agboola; A Girard
Journal:  J Neurooncol       Date:  1997-04       Impact factor: 4.130

2.  In vitro potentiation of BCNU activity in rat brain tumour cells pretreated with misonidazole.

Authors:  D W Siemann; K Wolf; S Morrissey; K T Wheeler
Journal:  Br J Cancer       Date:  1984-06       Impact factor: 7.640

3.  Bleomycin and misonidazole cytotoxicity.

Authors:  M Korbelik; B Palcic; L D Skarsgard
Journal:  Br J Cancer       Date:  1985-04       Impact factor: 7.640

4.  Hypoxic cells and in situ chemopotentiation of the nitrosoureas by misonidazole.

Authors:  K T Wheeler; C A Wallen; K L Wolf; D W Siemann
Journal:  Br J Cancer       Date:  1984-06       Impact factor: 7.640

5.  Potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea's toxicity in vitro by two new bioreductive agents.

Authors:  M V Papadopoulou; A Mainwaring; W D Bloomer
Journal:  Jpn J Cancer Res       Date:  1992-08

6.  Chemopotentiation in vivo: no loss of sensitization with fractionation.

Authors:  S A Hill; D W Siemann
Journal:  Br J Cancer       Date:  1984-10       Impact factor: 7.640

7.  Enhancement of the DNA cross-linking activity of melphalan by misonidazole in vivo.

Authors:  D Murray; R E Meyn
Journal:  Br J Cancer       Date:  1983-02       Impact factor: 7.640

8.  Oxygen dependence for chemosensitization by misonidazole.

Authors:  L Roizin-Towle; E J Hall; J P Pirro
Journal:  Br J Cancer       Date:  1986-12       Impact factor: 7.640

9.  Enhancing effect of pre-treatment of cells with misonidazole in hypoxia on their response to melphalan in air.

Authors:  E Smith; I J Stratford; G E Adams
Journal:  Br J Cancer       Date:  1982-07       Impact factor: 7.640
  9 in total

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