Literature DB >> 6166444

Nasal decongestants.

D W Empey, K T Medder.   

Abstract

When a patient presents with nasal obstruction a correct diagnosis must be made. Treatment may not always be required, and the need for intervention should be balanced against the risks of therapy. If the patient has an acute problem, such as the common cold or sinusitis, a topical decongestant may be the most immediately effective remedy, but this should never be continued for more than a few days and the patient should be warned against buying similar proprietary products. In more chronic cases, such as allergic or vasomotor rhinitis, or when decongestion of mucosa away from the nose (Eustachian tube) is required, oral treatment is best. A sympathomimetic administered orally (pseudoephedrine or phenylephrine) may be sufficient, or an antihistamine alone may be helpful in allergic rhinitis. Combination products are frequently effective, possibly more so than the individual ingredients, but when using such products the prescriber must remember the contraindications and precautions for each ingredient.

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Year:  1981        PMID: 6166444     DOI: 10.2165/00003495-198121060-00003

Source DB:  PubMed          Journal:  Drugs        ISSN: 0012-6667            Impact factor:   9.546


  13 in total

1.  A Double-blind crossover trial of pseudoephedrine and triprolidine, alone and in combination, for the treatment of allergenic rhinitis.

Authors:  D W Empey; C Bye; M Hodder; D T Hughes
Journal:  Ann Allergy       Date:  1975-01

2.  CLINICAL trials of antihistaminic drugs in the prevention and treatment of the common cold; report by a special committee of the Medical Research Council.

Authors: 
Journal:  Br Med J       Date:  1950-08-19

Review 3.  A review of antihistamines and the common cold.

Authors:  S West; B Brandon; P Stolley; R Rumrill
Journal:  Pediatrics       Date:  1975-07       Impact factor: 7.124

4.  Disodium cromoglycate in hayfever.

Authors:  L H Capel; P McKelvie
Journal:  Lancet       Date:  1971-03-20       Impact factor: 79.321

5.  Effects of pseudoephedrine and triprolidine, alone and in combination, on symptoms of the common cold.

Authors:  C E Bye; J Cooper; D W Empey; A S Fowle; D T Hughes; E Letley; J O'Grady
Journal:  Br Med J       Date:  1980-07-19

6.  Study of 2% solution of sodium cromoglycate in perennial rhinitis assessed by subjective and objective parameters.

Authors:  J P Girard; J Bertrand
Journal:  Clin Allergy       Date:  1975-09

7.  Local effect of intranasal beclomethasone dipropionate aerosol in hay fever.

Authors:  N Mygind
Journal:  Br Med J       Date:  1973-11-24

8.  Dose-response study of the nasal decongestant and cardiovascular effects of pseudoephedrine.

Authors:  D W Empey; G A Young; E Letley; G C John; P Smith; K A McDonnell; L R Bagg; D T Hughes
Journal:  Br J Clin Pharmacol       Date:  1980-04       Impact factor: 4.335

9.  The "nose drop nose" due to oxymetazoline (Afrin) and other topical vasoconstrictors.

Authors:  A R Feinberg; S M Feinberg
Journal:  IMJ Ill Med J       Date:  1971-07

10.  Flunisolide: a review of its pharmacological properties and therapeutic efficacy in rhinitis.

Authors:  G E Pakes; R N Brogden; R D Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1980-06       Impact factor: 9.546

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  5 in total

Review 1.  Chemotherapy of rhinovirus colds.

Authors:  S J Sperber; F G Hayden
Journal:  Antimicrob Agents Chemother       Date:  1988-04       Impact factor: 5.191

2.  Characterization of alpha-adrenoceptors in the vasculature of the canine nasal mucosa.

Authors:  T L Berridge; A G Roach
Journal:  Br J Pharmacol       Date:  1986-06       Impact factor: 8.739

3.  A Multicenter, Randomized, Placebo-Controlled Study of Pseudoephedrine for the Temporary Relief of Nasal Congestion in Children With the Common Cold.

Authors:  Cathy K Gelotte; Helmut H Albrecht; Jennifer Hynson; Valerie Gallagher
Journal:  J Clin Pharmacol       Date:  2019-07-05       Impact factor: 3.126

Review 4.  Enzyme Models-From Catalysis to Prodrugs.

Authors:  Zeinab Breijyeh; Rafik Karaman
Journal:  Molecules       Date:  2021-05-28       Impact factor: 4.411

5.  Pharmacokinetics, safety, and cardiovascular tolerability of phenylephrine HCl 10, 20, and 30 mg after a single oral administration in healthy volunteers.

Authors:  Cathy K Gelotte; Brenda A Zimmerman
Journal:  Clin Drug Investig       Date:  2015-09       Impact factor: 2.859

  5 in total

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