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Literature DB >> 6165894

Hormonal inducibility of rat alpha 2u globulin genes in transfected mouse cells.

Abstract

Two different genes coding for the hormonally regulated rat liver protein alpha 2u globulin were introduced into mouse Ltk- cells through co-transfection with the HSV-1 thymidine kinase gene. Three to ten copies of the alpha 2u globulin genes were detected several tk+ clones, over 50% of which could be induced with dexamethasone, the produce alha 2u globulin mRNA and protein. This suggests that the information necessary for hormonal response is contained in the DNA fragment used for transfer.

Entities: Chemical Gene Species

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Year: 1981 PMID： 6165894 DOI： 10.1038/291629a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

32 in total

1. Identification and characterization of functional genes encoding the mouse major urinary proteins.

Authors: W A Held; J F Gallagher; C M Hohman; N J Kuhn; B M Sampsell; R G Hughes
Journal: Mol Cell Biol Date: 1987-10 Impact factor: 4.272

2. Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment that mediates a delayed secondary response to glucocorticoids in vivo.

Authors: P Hess; T Meenakshi; G C Chan; J Carlstedt-Duke; J A Gustafsson; F Payvar
Journal: Proc Natl Acad Sci U S A Date: 1990-04 Impact factor: 11.205

3. Tissue restricted and stage specific transcription is maintained within 411 nucleotides flanking the 5' end of the chicken alpha-skeletal actin gene.

Authors: J M Grichnik; D J Bergsma; R J Schwartz
Journal: Nucleic Acids Res Date: 1986-02-25 Impact factor: 16.971

4. Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene.

Authors: E P Slater; O Rabenau; M Karin; J D Baxter; M Beato
Journal: Mol Cell Biol Date: 1985-11 Impact factor: 4.272

10. Polypeptide hormone regulation of gene transcription: specific 5' genomic sequences are required for epidermal growth factor and phorbol ester regulation of prolactin gene expression.

Authors: S C Supowit; E Potter; R M Evans; M G Rosenfeld
Journal: Proc Natl Acad Sci U S A Date: 1984-05 Impact factor: 11.205

Hormonal inducibility of rat alpha 2u globulin genes in transfected mouse cells.

1. Identification and characterization of functional genes encoding the mouse major urinary proteins.

2. Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment that mediates a delayed secondary response to glucocorticoids in vivo.

3. Tissue restricted and stage specific transcription is maintained within 411 nucleotides flanking the 5' end of the chicken alpha-skeletal actin gene.

4. Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene.

5. Differential requirements for cellular enhancers in stem and differentiated cells.

6. Tissue-specific and hormonally regulated expression of a rat alpha 2u globulin gene in transgenic mice.

7. Induction of human beta-interferon synthesis with poly(rI . rC) in mouse cells transfected with cloned cDNA plasmids.

8. Expression of abbreviated mouse dihydrofolate reductase genes in cultured hamster cells.

9. Expression and regulation of chicken actin genes introduced into mouse myogenic and nonmyogenic cells.

10. Polypeptide hormone regulation of gene transcription: specific 5' genomic sequences are required for epidermal growth factor and phorbol ester regulation of prolactin gene expression.