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Literature DB >> 6165438

A re-evaluation of the neurochemical and antinociceptive effects of intrathecal capsaicin in the rat.

Abstract

The effect of intrathecal administration of capsaicin in the rat on thermal nociceptive thresholds and on the content of substance P, somatostatin and glutamic acid decarboxylase in the dorsal horn of the spinal cord was determined. The results suggest that the depletion of spinal cord substance P induced by capsaicin may not by itself be sufficient to explain the observed changes in noxious thermal thresholds, which may be related instead to non-specific damage to the spinal cord.

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Year: 1981 PMID： 6165438 DOI： 10.1016/0006-8993(81)90980-x

Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252

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Cited

13 in total

1. Preoperative intraluminal application of capsaicin increases postoperative gastric and colonic motility in rats.

Authors: T T Zittel; T Meile; A Huge; M E Kreis; H D Becker; E C Jehle
Journal: J Gastrointest Surg Date: 2001 Sep-Oct Impact factor: 3.452

Review 2. The vanilloid agonist resiniferatoxin for interventional-based pain control.

Authors: Michael J Iadarola; Andrew J Mannes
Journal: Curr Top Med Chem Date: 2011 Impact factor: 3.295

3. Widespread distribution of substance P- and somatostatin-immunoreactive elements in the spinal cord of the neonatal rat.

Authors: R H Ho
Journal: Cell Tissue Res Date: 1983 Impact factor: 5.249

4. Central neural activation following contact sensitivity peripheral immune challenge: evidence of brain-immune regulation through C fibres.

Authors: Jeffrey S Thinschmidt; Michael A King; Maria Korah; Pablo D Perez; Marcelo Febo; Jaleel Miyan; Maria B Grant
Journal: Immunology Date: 2015-08-24 Impact factor: 7.397

A re-evaluation of the neurochemical and antinociceptive effects of intrathecal capsaicin in the rat.

1. Preoperative intraluminal application of capsaicin increases postoperative gastric and colonic motility in rats.

Review 2. The vanilloid agonist resiniferatoxin for interventional-based pain control.

3. Widespread distribution of substance P- and somatostatin-immunoreactive elements in the spinal cord of the neonatal rat.

4. Central neural activation following contact sensitivity peripheral immune challenge: evidence of brain-immune regulation through C fibres.

5. Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation.

6. Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro.

7. Capsaicin and nociception in the rat and mouse. Possible role of substance P.

8. Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control.

9. TRPV1: a target for next generation analgesics.

10. Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia.