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Literature DB >> 6180329

Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro.

J Sawynok, N Kato, V Havlicek, F S LaBella.

Abstract

High concentrations of K+ increase the release of substance P (SP) and somatostatin (SRIF) from superfused slices of rat spinal cord. This increase is Ca-dependent. Baclofen (100-500 microM) does not significantly alter the K+-evoked release of SP or SRIF. Stereoisomers of baclofen and GABA, similarly, are without effect. The spinal analgesic action of baclofen does not appear to be due to alterations in the release of SP or SRIF.

Entities: Chemical Gene Species

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Year: 1982 PMID： 6180329 DOI： 10.1007/bf00491482

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

41 in total

1. Release of substance P-like immunoreactivity from isolated spinal cord of newborn rat.

Authors: M Otsuka; S Konishi
Journal: Nature Date: 1976-11-04 Impact factor: 49.962

2. Antagonism between Lioresal and substance P in rat spinal cord.

Authors: K Saito; S Konishi; M Otsuka
Journal: Brain Res Date: 1975-10-24 Impact factor: 3.252

3. Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat.

Authors: T Hökfelt; R Elde; O Johansson; R Luft; G Nilsson; A Arimura
Journal: Neuroscience Date: 1976 Impact factor: 3.590

Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro.

1. Release of substance P-like immunoreactivity from isolated spinal cord of newborn rat.

2. Antagonism between Lioresal and substance P in rat spinal cord.

3. Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat.

4. Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration.

5. Baclofen is antinociceptive in the spinal intrathecal space of animals.

6. Baclofen: effects on amino acid release and metabolism in slices of guinea pig cerebral cortex.

7. Immunoreactive somatostatin release from rat spinal cord in vitro.

8. Effects of baclofen on spinal neurones of cats.

9. Antinociceptive effects of baclofen and muscimol upon intraventricular administration.

10. Effects of substance P on nociceptive and non-nociceptive trigeminal brain stem neurons.

1. Release of substance P from the cat spinal cord.