Literature DB >> 6164737

Inhibition of axon reflex vasodilatation by topically applied capsaicin.

J E Bernstein, R M Swift, K Soltani, A L Lorincz.   

Abstract

Topical application of capsaicin to human skin produced an initial burning erythematous reaction which diminished over 24 hr leaving the skin unresponsive to histamine-induced axon reflex vasodilatation without altering sensitivity to pain, touch and temperature. Depletion of substance P from local sensory nerve terminals is suggested as a possible explanation for this capsaicin effect.

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Year:  1981        PMID： 6164737     DOI： 10.1111/1523-1747.ep12520912

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  18 in total

1.  Effect of topically applied capsaicin on the cutaneous reaction to histamine.

Authors:  S Imai
Journal:  Arch Dermatol Res       Date:  1991       Impact factor: 3.017

2.  Direct evidence of neurally mediated vasodilatation in hairy skin of the human foot.

Authors:  H Blumberg; B G Wallin
Journal:  J Physiol       Date:  1987-01       Impact factor: 5.182

3.  Topical capsaicin pretreatment inhibits axon reflex vasodilatation caused by somatostatin and vasoactive intestinal polypeptide in human skin.

Authors:  P Anand; S R Bloom; G P McGregor
Journal:  Br J Pharmacol       Date:  1983-04       Impact factor: 8.739

4.  Antidromic vasodilatation and neurogenic inflammation.

Authors:  J Szolcsányi
Journal:  Agents Actions       Date:  1988-02

Review 5.  Eye of newt and toe of frog: substance P and the charmed pot of neuropeptides.

Authors:  P Skrabanek
Journal:  Ir J Med Sci       Date:  1984-02       Impact factor: 1.568

6.  Histamine release and vascular changes induced by neuropeptides.

Authors:  J Foreman; C Jordan
Journal:  Agents Actions       Date:  1983-04

7.  Local and systemic capsaicin pretreatment inhibits sneezing and the increase in nasal vascular permeability induced by certain chemical irritants.

Authors:  L Lundblad; J M Lundberg; A Anggård
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-06       Impact factor: 3.000

8.  Variation in cutaneous perfusion due to synthetic pyrethroid exposure.

Authors:  S A Flannigan; S B Tucker
Journal:  Br J Ind Med       Date:  1985-11

9.  The actions of capsaicin applied topically to the skin of the rat on C-fibre afferents, antidromic vasodilatation and substance P levels.

Authors:  B Lynn; W Ye; B Cotsell
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739

10.  Intradermal actions of hypertonic saline involve neural and vascular mechanisms.

Authors:  A M Sharara; M A Higham; M J Iredale; P W Ind
Journal:  Br J Clin Pharmacol       Date:  1995-07       Impact factor: 4.335
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