Literature DB >> 6133573

Topical capsaicin pretreatment inhibits axon reflex vasodilatation caused by somatostatin and vasoactive intestinal polypeptide in human skin.

P Anand, S R Bloom, G P McGregor.   

Abstract

1 Wheal and flare reactions are described following intradermal injections of somatostatin, vasoactive intestinal polypeptide, substance P and histamine in normal human forearm skin. Bombesin failed to produce a significant wheal and flare.2 Pretreatment of skin with capsaicin in all cases dramatically inhibited the flare but not the wheal. This result is in accord with the hypothesis that capsaicin blocks the effector side of the axon reflex, perhaps by depleting nerve terminals of vasodilatory peptide(s).

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6133573      PMCID： PMC2044739          DOI： 10.1111/j.1476-5381.1983.tb09418.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  24 in total

Review 1.  Autonomic neuroeffector junctions--reflex vasodilatation of the skin.

Authors:  G Burnstock
Journal:  J Invest Dermatol       Date:  1977-07       Impact factor: 8.551

2.  The value of axon responses in determining the site of lesion in traction injuries of the brachial plexus.

Authors:  G BONNEY
Journal:  Brain       Date:  1954-12       Impact factor: 13.501

3.  Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat.

Authors:  T Hökfelt; R Elde; O Johansson; R Luft; G Nilsson; A Arimura
Journal:  Neuroscience       Date:  1976       Impact factor: 3.590

4.  Peptide neurons in the vagus, splanchnic and sciatic nerves.

Authors:  J M Lundberg; T Hökfelt; G Nilsson; L Terenius; J Rehfeld; R Elde; S Said
Journal:  Acta Physiol Scand       Date:  1978-12

5.  Release of histamine from mast cells by vasoactive peptides.

Authors:  A R Johnson; E G Erdös
Journal:  Proc Soc Exp Biol Med       Date:  1973-04

6.  Release of vasoactive intestinal polypeptide in mast cells by histamine liberators.

Authors:  E Cutz; W Chan; N S Track; A Goth; S I Said
Journal:  Nature       Date:  1978-10-19       Impact factor: 49.962

7.  Decrease of substance P in primary afferent neurones and impairment of neurogenic plasma extravasation by capsaicin.

Authors:  R Gamse; P Holzer; F Lembeck
Journal:  Br J Pharmacol       Date:  1980-02       Impact factor: 8.739

8.  Flare and itch induced by substance P in human skin.

Authors:  O Hägermark; T Hökfelt; B Pernow
Journal:  J Invest Dermatol       Date:  1978-10       Impact factor: 8.551

9.  Substance P: a naturally occurring transmitter in human spinal cord.

Authors:  A C Cuello; J M Polak; A G Pearse
Journal:  Lancet       Date:  1976-11-13       Impact factor: 79.321

10.  Modification by capsaicin and compound 48/80 of dye leakage induced by irritants in the rat.

Authors:  P T Arvier; L A Chahl; R J Ladd
Journal:  Br J Pharmacol       Date:  1977-01       Impact factor: 8.739
View more
  13 in total

1.  Cutaneous nociception and neurogenic inflammation evoked by PACAP38 and VIP.

Authors:  Henrik Winther Schytz; Helle Holst; Lars Arendt-Nielsen; Jes Olesen; Messoud Ashina
Journal:  J Headache Pain       Date:  2010-05-09       Impact factor: 7.277

2.  Effect of topically applied capsaicin on the cutaneous reaction to histamine.

Authors:  S Imai
Journal:  Arch Dermatol Res       Date:  1991       Impact factor: 3.017

3.  Cutaneous blood flow responses in the forearms of Raynaud's patients induced by local cooling and intradermal injections of CGRP and histamine.

Authors:  S D Brain; R G Petty; J D Lewis; T J Williams
Journal:  Br J Clin Pharmacol       Date:  1990-12       Impact factor: 4.335

Review 4.  Mast cells, neuropeptides and inflammation.

Authors:  M K Church; M A Lowman; P H Rees; R C Benyon
Journal:  Agents Actions       Date:  1989-04

5.  Characterization of neuropeptide-induced histamine release from human dispersed skin mast cells.

Authors:  M A Lowman; R C Benyon; M K Church
Journal:  Br J Pharmacol       Date:  1988-09       Impact factor: 8.739

6.  NK-1 receptor mediation of neurogenic plasma extravasation in rat skin.

Authors:  P V Andrews; R D Helme; K L Thomas
Journal:  Br J Pharmacol       Date:  1989-08       Impact factor: 8.739

7.  On the actions of substance P, somatostatin, and vasoactive intestinal polypeptide on rat peritoneal mast cells and in human skin.

Authors:  W Piotrowski; J C Foreman
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-12       Impact factor: 3.000

8.  Effects of capsaicin on cutaneous vasodilator responses in humans.

Authors:  R G Roberts; R A Westerman; R E Widdop; R R Kotzmann; R Payne
Journal:  Agents Actions       Date:  1992-09

9.  Blockade of the flare response to intradermal 5-hydroxytryptamine in man by MDL 72.222, a selective antagonist at neuronal 5-hydroxytryptamine receptors.

Authors:  J M Orwin; J R Fozard
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

10.  Marked depletion of dorsal spinal cord substance P and calcitonin gene-related peptide with intact skin flare responses in multiple system atrophy.

Authors:  P Anand; R Bannister; G P McGregor; M A Ghatei; P K Mulderry; S R Bloom
Journal:  J Neurol Neurosurg Psychiatry       Date:  1988-02       Impact factor: 10.154
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.