Literature DB >> 6163461

Protective effects of osmotic stabilizers on morphological and permeability alterations induced in Vero cells by Clostridium perfringens enterotoxin.

B A McClane, J L McDonel.   

Abstract

Culture medium made hypertonic by the addition of osmotic stabilizers such as sucrose, poly(ethylene glycol), dextran and bovine serum albumin protected against changes in morphology and plasma membrane permeability induced by Clostridium perfringes enterotoxin. The protection did not appear to be due to binding inhibition. Results of these studies support an osmotic disruption mechanism for the action of the enterotoxin. A comprehensive model of the enterotoxin's action based on an osmotic disruption mechanism is proposed.

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Year:  1981        PMID： 6163461     DOI： 10.1016/0005-2736(81)90496-x

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  15 in total

1.  Death pathways activated in CaCo-2 cells by Clostridium perfringens enterotoxin.

Authors:  Ganes Chakrabarti; Xin Zhou; Bruce A McClane
Journal:  Infect Immun       Date:  2003-08       Impact factor: 3.441

2.  Deletion analysis of the Clostridium perfringens enterotoxin.

Authors:  J F Kokai-Kun; B A McClane
Journal:  Infect Immun       Date:  1997-03       Impact factor: 3.441

3.  Clostridium perfringens enterotoxin damages the human intestine in vitro.

Authors:  M E Fernández Miyakawa; V Pistone Creydt; F A Uzal; B A McClane; C Ibarra
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

4.  Evaluation of ELISA, RPLA, and Vero cell assays for detecting Clostridium perfringens enterotoxin in faecal specimens.

Authors:  P R Berry; J C Rodhouse; S Hughes; B A Bartholomew; R J Gilbert
Journal:  J Clin Pathol       Date:  1988-04       Impact factor: 3.411

5.  Morphological alterations and changes in cellular cations induced by Clostridium perfringens type A enterotoxin in tissue culture cells.

Authors:  N Sugimoto; K Ozutsumi; M Matsuda
Journal:  Eur J Epidemiol       Date:  1985-12       Impact factor: 8.082

6.  Transmembrane pore size and role of cell swelling in cytotoxicity caused by Pasteurella haemolytica leukotoxin.

Authors:  K D Clinkenbeard; D A Mosier; A W Confer
Journal:  Infect Immun       Date:  1989-02       Impact factor: 3.441

7.  Isolation and function of a Clostridium perfringens enterotoxin fragment.

Authors:  Y Horiguchi; T Akai; G Sakaguchi
Journal:  Infect Immun       Date:  1987-12       Impact factor: 3.441

8.  Identification of a Clostridium perfringens enterotoxin region required for large complex formation and cytotoxicity by random mutagenesis.

Authors:  J F Kokai-Kun; K Benton; E U Wieckowski; B A McClane
Journal:  Infect Immun       Date:  1999-11       Impact factor: 3.441

9.  Molecular cloning of the 3' half of the Clostridium perfringens enterotoxin gene and demonstration that this region encodes receptor-binding activity.

Authors:  P C Hanna; A P Wnek; B A McClane
Journal:  J Bacteriol       Date:  1989-12       Impact factor: 3.490

10.  Evidence that a region(s) of the Clostridium perfringens enterotoxin molecule remains exposed on the external surface of the mammalian plasma membrane when the toxin is sequestered in small or large complexes.

Authors:  J F Kokai-Kun; B A McClane
Journal:  Infect Immun       Date:  1996-03       Impact factor: 3.441
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