Literature DB >> 6163216

Induction of hemoglobin accumulation in human K562 cells by hemin is reversible.

A Dean, F Erard, A P Schneider, A N Schechter.   

Abstract

Twenty micromolar hemin causes no change in the rate of division of K562 cells but results in accumulation of 11 to 14 picograms of embryonic and fetal hemoglobins per cell. This effect is reversible, and hemoglobin induction in response to hemin, and loss of hemoglobin upon removal of hemin, can be cyclically repeated. The cells can be indefinitely subcultured in the presence of the inducer. Thus, the control of hemoglobin levels in K562 cells does not depend on irreversible differentiation.

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Year:  1981        PMID： 6163216     DOI： 10.1126/science.6163216

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  20 in total

1.  Synergism between hypersensitive sites confers long-range gene activation by the beta-globin locus control region.

Authors:  E H Bresnick; L Tze
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-29       Impact factor: 11.205

2.  Aproliferin--a human plasma protein that induces the irreversible loss of proliferative potential associated with terminal differentiation.

Authors:  M L Wier; R E Scott
Journal:  Am J Pathol       Date:  1986-12       Impact factor: 4.307

3.  Mapping of DNase I-hypersensitive sites in the upstream DNA of human embryonic epsilon-globin gene in K562 leukemia cells.

Authors:  D Tuan; I M London
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

Review 4.  Genetic modifications during cellular aging.

Authors:  S Goldstein; R J Shmookler Reis
Journal:  Mol Cell Biochem       Date:  1984-09       Impact factor: 3.396

5.  The outcome of poliovirus infections in K562 cells is cytolytic rather than persistent after hemin-induced differentiation.

Authors:  P A Benton; D J Barrett; R L Matts; R E Lloyd
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

6.  Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera.

Authors:  Fabiana Perna; Nadia Gurvich; Ruben Hoya-Arias; Omar Abdel-Wahab; Ross L Levine; Takashi Asai; Francesca Voza; Silvia Menendez; Lan Wang; Fan Liu; Xinyang Zhao; Stephen D Nimer
Journal:  Blood       Date:  2010-06-28       Impact factor: 22.113

7.  Developmental stage differences in chromatin subdomains of the beta-globin locus.

Authors:  AeRi Kim; Ann Dean
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-22       Impact factor: 11.205

8.  A non-apoptotic function of caspase-3 in pharmacologically-induced differentiation of K562 cells.

Authors:  M Sztiller-Sikorska; J Jakubowska; M Wozniak; M Stasiak; M Czyz
Journal:  Br J Pharmacol       Date:  2009-07-20       Impact factor: 8.739

9.  Multiple post-transcriptional regulatory mechanisms in ferritin gene expression.

Authors:  E Mattia; J den Blaauwen; G Ashwell; J van Renswoude
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

10.  Induction of terminal differentiation in human K562 erythroleukemia cells by arabinofuranosylcytosine.

Authors:  C Luisi-DeLuca; T Mitchell; D Spriggs; D W Kufe
Journal:  J Clin Invest       Date:  1984-09       Impact factor: 14.808
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