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Literature DB >> 6162459

A novel and comprehensive synthetic approach for the elucidation of protein antigenic structures. Determination of the full antigenic profile of the alpha-chain of human haemoglobin.

Abstract

A comprehensive synthetic approach for the determination of continuous antigenic sites of proteins is presented. This approach consists of the synthesis of a series of consecutive overlapping peptides that, together, systematically represent the entire primary structure of the protein under study. Its application to the alpha-chain of human haemoglobin afforded, for the first time, a full profile of immunochemically active alpha-chain peptides and enabled the localization of all the major continuous antigenic sites of this haemoglobin subunit.

Entities: Gene Species

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Year: 1980 PMID： 6162459 PMCID： PMC1162207 DOI： 10.1042/bj1910261

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

13 in total

1. Preparation of iodine-131 labelled human growth hormone of high specific activity.

Authors: W M HUNTER; F C GREENWOOD
Journal: Nature Date: 1962-05-05 Impact factor: 49.962

2. Immunochemistry of sperm-whale myoglobin. 18. Accurate delineation of the single reactive region in sequence 120-153 by study of synthetic peptides.

Authors: J Koketsu; M Z Atassi
Journal: Biochim Biophys Acta Date: 1973-12-06

3. A simplified method for cyanogen bromide activation of agarose for affinity chromatography.

Authors: S C March; I Parikh; P Cuatrecasas
Journal: Anal Biochem Date: 1974-07 Impact factor: 3.365

4. Immunochemistry of sperm-whale myoglobin. XVI. Accurate delineation of the single region in sequence 1-55 by immunochemical studies of synthetic peptides. Some conclusions concerning antigenic structures of proteins.

Authors: J Koketsu; M Z Atassi
Journal: Immunochemistry Date: 1974-01

5. The demonstration of two gamma-globulin subclasses in the goat.

Authors: G D Gray; M M Mickelson; J A Crim
Journal: Immunochemistry Date: 1969-09

6. Chemical studies on haemoglobins A1 and A0.

Authors: M Z Atassi
Journal: Biochem J Date: 1964-10 Impact factor: 3.857

7. A proposal for the nomenclature of antigenic sites in peptides and proteins.

Authors: M Z Atassi; J A Smith
Journal: Immunochemistry Date: 1978-08

8. Precise determination of the entire antigenic structure of lysozyme: molecular features of protein antigenic structures and potential of "surface-simulation" synthesis--a powerful new concept for protein binding sites.

Authors: M Z Atassi
Journal: Immunochemistry Date: 1978-12

9. Prediction and conformation by synthesis of two antigenic sites in human haemoglobin by extrapolation from the known antigenic structure of sperm-whale myoglobin.

Authors: A L Kazim; M Z Atassi
Journal: Biochem J Date: 1977-10-01 Impact factor: 3.857

Review 10. Antigenic structure of myoglobin: the complete immunochemical anatomy of a protein and conclusions relating to antigenic structures of proteins.

Authors: M Z Atassi
Journal: Immunochemistry Date: 1975-05

30 in total

1. Effects of amino acid substitutions outside an antigenic site on protein binding to monoclonal antibodies of predetermined specificity obtained by peptide immunization: demonstration with region 113-120 (antigenic site 4) of myoglobin.

Authors: M S Abaza; M Z Atassi
Journal: J Protein Chem Date: 1992-12

2. Antigenic mapping of a human lambda light chain: correlation with three dimensional structure.

Authors: J J Marchalonis; F Dedeoglu; H Kaymaz; S F Schluter; A B Edmundson
Journal: J Protein Chem Date: 1992-04

3. Generation of species-specific antihemoglobin antibodies by immunization with synthetic peptides of human hemoglobin.

Authors: M Oshima; M Z Atassi
Journal: J Protein Chem Date: 1989-12

4. Profile of the continuous antigenic regions on the extracellular part of the alpha chain of an acetylcholine receptor.

Authors: B Mulac-Jericević; J Kurisaki; M Z Atassi
Journal: Proc Natl Acad Sci U S A Date: 1987-06 Impact factor: 11.205

5. Antigenic structure of human haemoglobin. Localization of the antigenic sites of the beta-chain in three host species by synthetic overlapping peptides representing the entire chain.

Authors: N Yoshioka; M Z Atassi
Journal: Biochem J Date: 1986-03-01 Impact factor: 3.857

6. T cells specific for alpha-beta interface regions of hemoglobin recognize the isolated subunit but not the tetramer and indicate presentation without processing.

Authors: M Z Atassi; M Yoshioka; G S Bixler
Journal: Proc Natl Acad Sci U S A Date: 1989-09 Impact factor: 11.205

7. Conformation-dependent recognition of a protein by T cells requires presentation without processing.

Authors: M Z Atassi; G S Bixler; T Yokoi
Journal: Biochem J Date: 1989-05-01 Impact factor: 3.857

8. Profile of the alpha-bungarotoxin-binding regions on the extracellular part of the alpha-chain of Torpedo californica acetylcholine receptor.

Authors: B Mulac-Jericevic; M Z Atassi
Journal: Biochem J Date: 1987-12-15 Impact factor: 3.857

9. Seventh International Conference on Methods in Protein Sequence Analysis. July 3-8, 1988, West Berlin, F.R.G. Short communications.

Authors:
Journal: J Protein Chem Date: 1988-06

10. Molecular characterization of human Ro/SS-A antigen. Amino terminal sequence of the protein moiety of human Ro/SS-A antigen and immunological activity of a corresponding synthetic peptide.

Authors: T S Lieu; M M Newkirk; J D Capra; R D Sontheimer
Journal: J Clin Invest Date: 1988-07 Impact factor: 14.808