Intradermal histamine releasing effect caused by Org-NC 45. A comparison with pancuronium, metocurine and d-tubocurarine.

Histamine release caused by Org-NC 45, pancuronium, metocurine and d-tubocurarine was determined by measuring the diameter of the redness and skin induration following the intradermal injection of these drugs. d-Tubocurarine and metocurine caused the largest diameter of redness and induration, followed by pancuronium. Org-NC 45 caused the smallest reaction. We conclude that Org-NC 45 may be the drug of choice in patients with asthma and allergic reactions.