Literature DB >> 6122196

Org-NC45: a new steroidal non-depolarizing muscle relaxant.

L H Booij, T B Vree, J E Crul.   

Abstract

Although pancuronium has fewest side effects compared to other currently used non-depolarizing muscle relaxants, it is still not the ideal relaxant. Its structural analogues have been studied to derive such an ideal relaxant. Org-NC45 meets the requirements for such a relaxant best and is therefore extensively studied. It is more potent than pancuronium, has a shorter onset and duration of action and is free from cardiovascular side effects. Histamine release could not be demonstrated. It can be easily reversed by neostigmine, pyridostigmine or 4-aminopyridine. Interaction with antibiotics and anaesthetic drugs is not different from that of pancuronium.

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Year:  1982        PMID： 6122196     DOI： 10.1007/bf02112349

Source DB:  PubMed          Journal:  Pharm Weekbl Sci        ISSN： 0167-6555


  30 in total

1.  Some effects of the steroidal muscle relaxant, dacuronium bromide, in anaesthetized patients.

Authors:  J Norman; R L Katz
Journal:  Br J Anaesth       Date:  1971-04       Impact factor: 9.166

2.  Comparison of the neuromuscular blocking properties of ORG NC 45 and pancuronium in the rat, cat and rhesus monkey.

Authors:  N N Durant; M C Houwertjes; J F Crul
Journal:  Br J Anaesth       Date:  1980-08       Impact factor: 9.166

3.  The relationship between disposition and duration of action of congeneric series of steroidal neuromuscular blocking agents.

Authors:  S Agoston; E J Crul; U W Kersten; M C Houwertjes; A H Scaf
Journal:  Acta Anaesthesiol Scand       Date:  1977       Impact factor: 2.105

4.  Initial studies in man with a new myoneural blocking agent (ORG.6368).

Authors:  W L Baird
Journal:  Br J Anaesth       Date:  1974-09       Impact factor: 9.166

5.  The neuromuscular blocking properties of a new steroid compound, pancuronium bromide. A pilot study in man.

Authors:  W L Baird; A M Reid
Journal:  Br J Anaesth       Date:  1967-10       Impact factor: 9.166

6.  On the pharmacology of Org 6338 (2beta, 16beta-dipiperidino - 5alpha - androstan - 3alpha - ol acetate dimethobromide), a new steroidal neuromuscular blocking agent.

Authors:  M F Sugrue; N Duff; I McIndewar
Journal:  J Pharm Pharmacol       Date:  1975-10       Impact factor: 3.765

7.  Intradermal histamine releasing effect caused by Org-NC 45. A comparison with pancuronium, metocurine and d-tubocurarine.

Authors:  L H Booij; N Krieg; J F Crul
Journal:  Acta Anaesthesiol Scand       Date:  1980-10       Impact factor: 2.105

8.  The neuromuscular and autonomic blocking activities of pancuronium, Org NC 45, and other pancuronium analogues, in the cat.

Authors:  N N Durant; I G Marshall; D S Savage; D J Nelson; T Sleigh; I C Carlyle
Journal:  J Pharm Pharmacol       Date:  1979-12       Impact factor: 3.765

9.  Pharmacokinetics and pharmacodynamics of Org NC 45 in man.

Authors:  F van der Veen; A Bencini
Journal:  Br J Anaesth       Date:  1980       Impact factor: 9.166

10.  Cardiovascular and neuromuscular effects of Org NC 45, pancuronium, metocurine, and d-tubocurarine in dogs.

Authors:  L H Booij; R P Edwards; Y J Sohn; R D Miller
Journal:  Anesth Analg       Date:  1980-01       Impact factor: 5.108
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