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Literature DB >> 6156378

Uncharged tRNA inhibits guanosine 3',5'-bis (diphosphate) 3'-pyrophosphohydrolase [ppGppase], the spoT gene product, from Escherichia coli.

Abstract

The spot gene product from Escherichia coli, the guanosine 3',5'-bis(diphosphate) 3'-pyrophos phohydrolase [ppGppase] catalyzes the specific release of pyrophosphate from the 3'-position of guanosine 3',5'-bis(diphosphate) [ppGpp]; this reaction is significantly inhibited in the presence of uncharged tRNAPhe yeast. Little or no inhibition is observed with Phe-tRNAPhe, tRNAPhe-CpCpAoxi-red or ribosomal RNA (16S and 23S).

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1980 PMID： 6156378 DOI： 10.1007/BF00270479

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

6 in total

1. The guanosine 3',5'-bis(diphosphate) (ppGpp) cycle. Comparison of synthesis and degradation of guanosine 3',5'-bis(diphosphate) in various bacterial systems.

Authors: D Richter; S Fehr; R Harder
Journal: Eur J Biochem Date: 1979-08-15

2. Role of the aminoacyl end of transfer RNA in the allosteric control of guanosine pentaphosphate synthesis by the stringent factor-ribosome complex of Escherichia coli.

Authors: G Chinali; R Liou; J Ofengand
Journal: Biochemistry Date: 1978-07-11 Impact factor: 3.162

3. Regulation of RNA synthesis in Escherichia coli. III. Degradation of guanosine 5'-diphosphate 3'-diphosphate in cold-shocked cells.

Authors: H A Raué; M Cashel
Journal: Biochim Biophys Acta Date: 1975-03-21

4. Free 3'-OH group of the terminal adenosine of the tRNA molecule is essential for the synthesis in vitro of guanosine tetraphosphate and pentaphosphate in a ribosomal system from Escherichia coli.

Authors: M Sprinzl; D Richter
Journal: Eur J Biochem Date: 1976-12

5.

Authors: F Cramer; F v.d. Haar; E Schlimme
Journal: FEBS Lett Date: 1968-12 Impact factor: 4.124

6. Specificity of elongation factor Tu from Escherichia coli with respect to attachment to the amino acid to the 2' or 3'-hydroxyl group of the terminal adenosine of tRNA.

Authors: M Sprinzl; M Kucharzewski; J B Hobbs; F Cramer
Journal: Eur J Biochem Date: 1977-08-15

6 in total

9 in total

1. Activation of RelA by pppGpp as the basis for its differential toxicity over ppGpp in Escherichia coli.

Authors: Rajeshree Sanyal; Rajendran Harinarayanan
Journal: J Biosci Date: 2020 Impact factor: 1.826

2. Comparison of DeltarelA strains of Escherichia coli and Salmonella enterica serovar Typhimurium suggests a role for ppGpp in attenuation regulation of branched-chain amino acid biosynthesis.

Authors: K Tedin; F Norel
Journal: J Bacteriol Date: 2001-11 Impact factor: 3.490

3. Cellular localization of the Escherichia coli SpoT protein.

Authors: D R Gentry; M Cashel
Journal: J Bacteriol Date: 1995-07 Impact factor: 3.490

4. Depletion of the non-coding regulatory 6S RNA in E. coli causes a surprising reduction in the expression of the translation machinery.

Authors: Thomas Neusser; Tino Polen; René Geissen; Rolf Wagner
Journal: BMC Genomics Date: 2010-03-11 Impact factor: 3.969

9. Studies on the Regulation of (p)ppGpp Metabolism and Its Perturbation Through the Over-Expression of Nudix Hydrolases in Escherichia coli.

Authors: Rajeshree Sanyal; Allada Vimala; Rajendran Harinarayanan
Journal: Front Microbiol Date: 2020-10-15 Impact factor: 5.640