| Literature DB >> 6155067 |
J W Stoerner, I J Butler, F H Morriss, R R Howell, W E Seifert, R M Caprioli, E W Adcock, S E Denson.
Abstract
A female newborn infant with Marfan-like habitus experienced lethargy and hypothermia associated with tyrosinemia that was not corrected by the administration of ascorbic acid at 50 mg/day but that subsequently responded to ascorbic acid at 500 mg/day. Cerebrospinal fluid analysis for neurotransmitter metabolites showed elevated concentrations of homovanillic acid and 5-hydroxyindoleacetic acid when the child was symptomatic and normal concentrations after successful ascrobic acid therapy. These observations suggest that a high level of tyrosine in serum can affect the metabolism in the brain of dopamine and serotonin.Entities:
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Year: 1980 PMID： 6155067 DOI： 10.1001/archpedi.1980.02130170042014
Source DB: PubMed Journal: Am J Dis Child ISSN： 0002-922X