Literature DB >> 6154716

Determination of tryptophan and metabolites in rat brain and pineal tissue by reversed-phase high-performance liquid chromatography with electrochemical detection.

I N Mefford, J D Barchas.   

Abstract

Tryptophan and many of its indole metabolites were separated using reversed-phase high-performance liquid chromatography (HPLC) and determined using electrochemical detection. This was accomplished isocratically using an acetate--citric acid eluent with various amounts of methanol. Brain and pineal tissue was analyzed for several tryptophan metabolites. Tissue preparation required only homogenization in acidic solution and centrifugation prior to application to the HPLC column. Detection limits in the low picogram range were found for those indoles separated.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6154716     DOI： 10.1016/s0378-4347(00)81604-7

Source DB:  PubMed          Journal:  J Chromatogr


  10 in total

1.  Altered tryptophan metabolism in human meningioma.

Authors:  Noble Kumar Talari; Manas Panigrahi; Sailaja Madigubba; Sundaram Challa; Prakash Babu Phanithi
Journal:  J Neurooncol       Date:  2016-07-29       Impact factor: 4.130

2.  HeLa cells cocultured with peripheral blood lymphocytes acquire an immuno-inhibitory phenotype through up-regulation of indoleamine 2,3-dioxygenase activity.

Authors:  Grant J Logan; Christine M F Smyth; John W Earl; Irina Zaikina; Peter B Rowe; Jason A Smythe; Ian E Alexander
Journal:  Immunology       Date:  2002-04       Impact factor: 7.397

3.  The organochlorine insecticide 1,2,3,4,5,6-hexachlorocyclohexane (lindane) but not 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) augments the nocturnal increase in pineal N-acetyltransferase activity and pineal and serum melatonin levels.

Authors:  A M Attia; M H Mostafa; S A Soliman; A H el-Sebae; K O Nonaka; B Withyachumnarnkul; R J Reiter
Journal:  Neurochem Res       Date:  1990-07       Impact factor: 3.996

4.  Presence of P2-purinoceptors in the rat pineal gland.

Authors:  Z S Ferreira; J Cipolla-Neto; R P Markus
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739

5.  Simultaneous quantification of dopamine, 5-hydroxytryptamine and four metabolically related compounds by means of reversed-phase high-performance liquid chromatography with electrochemical detection.

Authors:  C D Kilts; G R Breese; R B Mailman
Journal:  J Chromatogr       Date:  1981-10-09

6.  Neither the pituitary gland nor the sympathetic nervous system is responsible for eliciting the large drop in elevated rat pineal melatonin levels due to swimming.

Authors:  M E Troiani; R J Reiter; M G Tannenbaum; M Puig-Domingo; J M Guerrero; A Menendez-Pelaez
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

7.  Hormonal modulation of pineal melatonin synthesis in rats and Syrian hamsters: effects of adrenalectomy and corticosteroid implants.

Authors:  T H Champney; C M Craft; S M Webb; R J Reiter
Journal:  J Neural Transm       Date:  1985       Impact factor: 3.575

8.  Serotonin metabolism in the CNS in cerebellar ataxic mice.

Authors:  K Ohsugi; K Adachi; K Ando
Journal:  Experientia       Date:  1986-12-01

9.  Serotonin and 5-hydroxyindoleacetic acid concentrations in individual hypothalamic nuclei and other brain areas of rat.

Authors:  K Oomagari; H Uchimura; T Matsumoto; H Yokoo; M Hirano; J S Kim; T Nakahara
Journal:  Experientia       Date:  1984-11-15

10.  The effect of curcumin on ethanol induced changes in suprachiasmatic nucleus (SCN) and pineal.

Authors:  Anita Jagota; M Y Reddy
Journal:  Cell Mol Neurobiol       Date:  2007-09-11       Impact factor: 5.046
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.