Literature DB >> 2430828

Serotonin metabolism in the CNS in cerebellar ataxic mice.

K Ohsugi, K Adachi, K Ando.   

Abstract

The metabolism of 5-hydroxytryptamine (5-HT) in the CNS was investigated in four kinds of morphologically different ataxic mice; reeler, staggerer, weaver and Purkinje cell degeneration mutants, and in hypocerebellar mice experimentally produced by injection of cytosine arabinoside. 5-HT and 5-hydroxyidoleacetic acid concentrations and tryptophan hydroxylase (TrpOH) activity were measured in the cerebrum, cerebellum and brain stem, respectively. TrpOH activity was significantly reduced only in the reeler mouse. The enhancements of the cerebellar 5-HT metabolism observed in the ataxic mice other than the reeler were supposed to be pseudo-enhancements subsequent to the cerebellar hypoplasia.

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Year:  1986        PMID： 2430828     DOI： 10.1007/bf01946406

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Anatomical, physiological and biochemical studies of the cerebellum from mutant mice. II. Morphological study of cerebellar cortical neurons and circuits in the weaver mouse.

Authors:  C Sotelo
Journal:  Brain Res       Date:  1975-08-22       Impact factor: 3.252

2.  Contents of several amino acids in the cerebellum, brain stem and cerebrum of the 'staggerer', 'weaver' and 'nervous' neurologically mutant mice.

Authors:  W J McBride; M H Aprison; K Kusano
Journal:  J Neurochem       Date:  1976-05       Impact factor: 5.372

3.  Biosynthesis of serotonin in Raphé nuclei of rat brain: effect of p-chlorophenylalanine.

Authors:  T Deguchi; A K Sinha; J D Barchas
Journal:  J Neurochem       Date:  1973-05       Impact factor: 5.372

4.  Activation of tryptophan hydroxylase by stimulation of central serotonergic neurons.

Authors:  M C Boadle-Biber; J N Johannessen; N Narasimhachari; T H Phan
Journal:  Biochem Pharmacol       Date:  1983-01-01       Impact factor: 5.858

5.  The cerebellar projection from the raphe nuclei in the cat as studied with the method of retrograde transport of horseradish peroxidase.

Authors:  E T Pierce; G H Hoddevik; F Walberg
Journal:  Anat Embryol (Berl)       Date:  1977-12-28

6.  Cytarabine and its effect on cerebellum of suckling mouse.

Authors:  M Shimada; S Wakaizumi; Y Kasubuchi; T Kusonoki
Journal:  Arch Neurol       Date:  1975-08

7.  Anatomical, physiological and biochemical studies of the cerebellum from mutant mice. I. Electrophysiological analysis of cerebellar cortical neurons in the staggerer mouse.

Authors:  F Crepel; J Mariani
Journal:  Brain Res       Date:  1975-11-07       Impact factor: 3.252

8.  Catecholamines in mutant mouse cerebellum: fluorescence microscopic and chemical studies.

Authors:  S C Landis; W J Shoemaker; M Schlumpf; F E Bloom
Journal:  Brain Res       Date:  1975-08-08       Impact factor: 3.252

9.  Central noradrenaline metabolism in cerebellar ataxic mice.

Authors:  O Muramoto; K Ando; I Kanazawa
Journal:  Brain Res       Date:  1982-04-15       Impact factor: 3.252

10.  Determination of tryptophan and metabolites in rat brain and pineal tissue by reversed-phase high-performance liquid chromatography with electrochemical detection.

Authors:  I N Mefford; J D Barchas
Journal:  J Chromatogr       Date:  1980-02-08
  10 in total
  3 in total

1.  Regional variations of 5HT concentrations in Rorasg (staggerer) mutants.

Authors:  Robert Lalonde; Catherine Strazielle
Journal:  Neurochem Res       Date:  2006-06-29       Impact factor: 3.996

2.  Effects of L-tryptophan on indoleamines and catecholamines in discrete brain regions of wild type and Lurcher mutant mice.

Authors:  T A Reader; N Le Marec; A R Ase; R Lalonde
Journal:  Neurochem Res       Date:  1999-09       Impact factor: 3.996

3.  The Discovery of the Monoaminergic Innervation of the Cerebellum: Convergence of Divergent and Point-to-Point Systems.

Authors:  Lazaros C Triarhou; Mario Manto
Journal:  Cerebellum       Date:  2022-09-23       Impact factor: 3.648
  3 in total

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