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Literature DB >> 6152220

Studies on the H2-receptor antagonism of MK-208 in isolated rabbit gastric glands.

Abstract

Using isolated rabbit gastric glands, the H2-receptor antagonist MK-208 was investigated with respect to its effects on [14C]aminopyrine uptake as an index of gastric acid secretion. In addition to shifting the histamine concentration-response curve to the right in a parallel fashion, the antagonism produced by MK-208 was reversible, contrary to that previously seen in the guinea pig atria. These observations suggest that the H2-receptors responsible for mediating gastric secretion in the rabbit and the chronotropic response in guinea pig atria are different.

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Year: 1984 PMID： 6152220 DOI： 10.1016/0014-2999(84)90733-7

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

11 in total

Review 1. Pharmacokinetic and pharmacodynamic properties of histamine H2-receptor antagonists. Relationship between intrinsic potency and effective plasma concentrations.

Authors: J H Lin
Journal: Clin Pharmacokinet Date: 1991-03 Impact factor: 6.447

2. Dimethyl sulfoxide inhibits histamine release induced by various chemicals.

Authors: L Candussio; F B Klugmann; G Decorti; S Bevilacqua; L Baldini
Journal: Agents Actions Date: 1987-02

Review 3. Famotidine. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in peptic ulcer disease and other allied diseases.

Authors: H D Langtry; S M Grant; K L Goa
Journal: Drugs Date: 1989-10 Impact factor: 9.546

4. H2-receptor antagonist and gastric acid antisecretory properties of Wy-45,662.

Authors: S T Nielsen
Journal: Agents Actions Date: 1986-11

5. Nutrient solution may alter the effect of the H2 blocker famotidine in the guinea pig papillary muscle.

Authors: E Poli; G Coruzzi; G Bertaccini
Journal: Agents Actions Date: 1989-11

6. Mechanism of action of H2-antagonists on histamine- or dimaprit-stimulated H2-receptors of spontaneously beating guinea-pig atrium.

Authors: M J Krielaart; D M Veenstra; K J van Buuren
Journal: Agents Actions Date: 1990-08

Studies on the H2-receptor antagonism of MK-208 in isolated rabbit gastric glands.

Review 1. Pharmacokinetic and pharmacodynamic properties of histamine H2-receptor antagonists. Relationship between intrinsic potency and effective plasma concentrations.

2. Dimethyl sulfoxide inhibits histamine release induced by various chemicals.

Review 3. Famotidine. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in peptic ulcer disease and other allied diseases.

4. H2-receptor antagonist and gastric acid antisecretory properties of Wy-45,662.

5. Nutrient solution may alter the effect of the H2 blocker famotidine in the guinea pig papillary muscle.

6. Mechanism of action of H2-antagonists on histamine- or dimaprit-stimulated H2-receptors of spontaneously beating guinea-pig atrium.

7. Further analysis of anomalous pKB values for histamine H2-receptor antagonists on the mouse isolated stomach assay.

8. Inhibitory effect of famotidine on cat gastric secretion.

9. Antisecretory and antiulcer effect of the H2-receptor antagonist famotidine in the rat: comparison with ranitidine.

10. Pharmacology of the novel H2 antagonist famotidine: in vitro studies.